Publications

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.

Zhang N, Zoltner M, Leung K-F, Scullion P, Hutchinson S, del Pino RC, et al. PLOS Pathog. 2018 Feb 9;14(2):e1006850..

Read More

Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.

Prati F, Zuccotto F, Fletcher D, Convery MA, Fernandez-Menendez R, Bates R, et al. ChemMedChem. 2018;13(7):672–7. Our findings reported herein..

Read More

Screening a protein kinase inhibitor library against Plasmodium falciparum.

Hallyburton I, Grimaldi R, Woodland A, Baragaña B, Luksch T, Spinks D, et al. Malar J [Internet]. 2017;16(1):446. Protein kinases..

Read More

Regulation of early endosomes across eukaryotes: Evolution and functional homology of Vps9 proteins.

Herman EK, Ali M, Field MC, Dacks JB. Traffic. 2018;19(7):546–63. Endocytosis is a crucial process in eukaryotic cells. The GTPases..

Read More

Exhaustive sampling of the fragment space associated to a molecule leading to the generation of conserved fragments.

Heikamp K, Zuccotto F, Kiczun M, Ray P, Gilbert IH. Chem Biol Drug Des. 2017;91(3):655–67. The first step in hit..

Read More

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.

Torrie LS, Brand S, Robinson DA, Ko EJ, Stojanovski L, Simeons FRC, et al. ACS Infect. Dis. 2017, 3, 10,..

Read More

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi.

Brand S, Ko EJ, Viayna E, Thompson S, Spinks D, Thomas M, et al J Med Chem. 2017;60(17):7284–99. Chagas’ disease,..

Read More

Fragment library design, synthesis and expansion: nurturing a synthesis and training platform.

Ray PC, Kiczun M, Huggett M, Lim A, Prati F, Gilbert IH, et al. Drug Discovery Today. 2017;22(1):43–56. The availability..

Read More