Publications

Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis

Fairlamb, Alan H and Patterson S. Current Medicinal Chemistry 25, 1–20, 2018 Interest in nitroheterocyclic drugs for the treatment of..

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Evolutionary origins and specialisation of membrane transport.

Dacks Joel B, Field Mark C. Curr Opin Cell Biol. 2018;53:70–6. From unicellular protists to the largest megafauna and flora, all eukaryotes depend upon..

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Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes.

Rico E, Jeacock L, Kovářová J, Horn D. Scientific Reports. 2018;8(1):7960. The Cas9 endonuclease can be programmed by guide RNA..

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Characterisation of a putative glutamate 5-kinase from Leishmania donovani.

Sienkiewicz N, Ong HB, Fairlamb AH. FEBS J. 2018;285(14):2662–78. Previous metabolic studies have demonstrated that leishmania parasites are able to..

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Generation of Polar Semi-Saturated Bicyclic Pyrazoles for Fragment-Based Drug-Discovery Campaigns.

Luise N, Wyatt PG Chem - A Eur J. 2018;24(41):10443–51 Synthesising polar semi‐saturated bicyclic heterocycles can lead to better starting..

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Proteomic analysis of the cell cycle of procylic form Trypanosoma brucei.

Crozier TWM, Tinti M, Wheeler RJ, Ly T, Ferguson MAJ, Lamond AI. Mol Cell Proteomics  [Internet]. 2018 Mar 19; We..

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Codon usage bias controls mRNA and protein abundance in trypanosomatids.

Jeacock L, Faria J, Horn D. elife. 2018;7:e32496. Protein abundance differs from a few to millions of copies per cell. Trypanosoma..

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2-Mercapto-quinazolinones as inhibitors of NDH-2 and Mycobacterium tuberculosis: Structure-activity relationships, mechanism of action and ADME characterization.

Murugesan D, Ray PC, Bayliss T, Prosser GA, Harrison JR, Green K, et al. ACS Infect. Dis. 2018, 4, 6,..

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Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.

Zhang N, Zoltner M, Leung K-F, Scullion P, Hutchinson S, del Pino RC, et al. PLOS Pathog. 2018 Feb 9;14(2):e1006850..

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Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.

Prati F, Zuccotto F, Fletcher D, Convery MA, Fernandez-Menendez R, Bates R, et al. ChemMedChem. 2018;13(7):672–7. Our findings reported herein..

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