Publications

Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani.

Victoriano Corpas-Lopez, Sonia Moniz, Michael Thomas, Richard J. Wall, Leah S. Torrie, Dorothea Zander-Dinse, Michele Tinti, Stephen Brand, Laste Stojanovski,..

Read More

Diversity-oriented synthesis of bicyclic fragments containing privileged azines.

Luise N, Wyatt PG Bioorg Med Chem Lett [Internet]. 2019;29(2):248–51 Abstract An innovative and efficient reagent- and scaffold-based diversity oriented..

Read More

Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei.

Kovářová J, Nagar R, Faria J, Ferguson MAJ, Barrett MP, Horn D. PLOS Pathog. 2018;14(12):e1007475. Bloodstream form African trypanosomes are..

Read More

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

Michael G. Thomas, Manu De Rycker, Myriam Ajakane, Sébastian Albrecht, Ana Isabel Álvarez-Pedraglio, Markus Boesche, Stephen Brand, Lorna Campbell, Juan..

Read More

2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease.

Thomas MG, De Rycker M, Cotillo Torrejon I, Thomas J, Riley J, Spinks D, et al. Bioorganic & Medicinal Chemistry..

Read More

Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome.

Webster LA, Thomas M, Urbaniak M, Wyllie S, Ong H, Tinti M, et al. ACS Infect. Dis. 2018, 4, 10,..

Read More

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3.

Wall RJ, Rico E, Lukac I, Zuccotto F, Elg S, Gilbert IH, et al. Proc Natl Acad Sci. 2018;201807915. African..

Read More

A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism.

Roberts AJ, Dunne J, Scullion P, Norval S, Fairlamb AH. Biochem J. 2018;BCJ20180232. Trypanosomatid parasites are the infectious agents causing..

Read More

Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future.

Smith PW, Zuccotto F, Bates RH, Martinez-Martinez MS, Read KD, Peet C, et al. ACS Infect. Dis. 2018, 4, 10,..

Read More

N-glycan microheterogeneity regulates interactions of plasma proteins.

Wu D, Struwe WB, Harvey DJ, Ferguson MAJ, Robinson C V. Proc Natl Acad Sci . 2018; 115 (35) 8763-8768 Altered glycosylation patterns..

Read More