The critical role of mode of action studies in kinetoplastid drug discovery

Alan H. Fairlamb and Susan Wyllie Front. Drug Discov., 10 May 2023 Sec. Anti-Infective Agents, Volume 3 - 2023 Understanding..

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum

Krittikorn Kümpornsin, Theerarat Kochakarn, Tomas Yeo, John Okombo, Madeline R. Luth, Johanna Hoshizaki, Mukul Rawat, Richard D. Pearson, Kyra A...

Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline

Oriana Kreutzfeld , Patrick K Tumwebaze , Martin Okitwi , Stephen Orena , Oswald Byaruhanga , Thomas Katairo , Melissa..

SophosQM: Accurate Binding Affinity Prediction in Compound Optimization

Riccardo Guareschi, Iva Lukac, Ian H. Gilbert, and Fabio Zuccotto ACS Omega 2023, 8, 17, 15083–15098 Abstract The optimization of compounds’..

Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022

Nicola Caldwell, Rana Afshar, Beatriz Baragaña, Amaya L. Bustinduy, Conor R. Caffrey, James J. Collins, Daniela Fusco, Amadou Garba, Mark..

Design and Synthesis of Covalent Inhibitors of FabA

James S. Martin, Claire J. Mackenzie, De Lin, Nadine Homeyer, David W. Gray, Fabio Zuccotto, and Ian H. Gilbert ACS..

Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation

Selina Bopp, Charisse Flerida A. Pasaje, Robert L. Summers, Pamela Magistrado-Coxen, Kyra A. Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok,..

Assessment of the drugability of initial malaria infection through miniaturized sporozoite assays and high-throughput screening

Marie Miglianico, Judith M. Bolscher, Martijn W. Vos, Karin J. M. Koolen, Marloes de Bruijni, Deeya S. Rajagopal, Emily Chen,..

The role of invariant surface glycoprotein 75 in xenobiotic acquisition by African trypanosomes

Alexandr Makarov, Jakub Began, Ileana Corvo Mautone, Erika Pinto, Liam Ferguson, Martin Zoltner, Sebastian Zoll and Mark C. Field. Microbial..

Peptidyl tRNA Hydrolase Is Required for Robust Prolyl-tRNA Turnover in Mycobacterium tuberculosis

Francesca G. Tomasi, Jessica T. P. Schweber, Satoshi Kimura, Junhao Zhu, Laura A. T. Cleghorn, Susan H. Davis, Simon R...

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