Publications

Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex.

Joana Faria, Lucy Glover, Sebastian Hutchinson, Cordula Boehm, Mark C. Field, David Horn. Nat Commun [Internet]. 2019;10(1):3023. Abstract The largest..

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Burkholderia pseudomallei D‐alanine‐D‐alanine ligase; detailed characterisation and assessment of a potential antibiotic drug target

Díaz-Sáez L, Torrie LS, McElroy SP, Gray D, Hunter WN FEBS J [Internet]. 2019;286(22):4509–24 Abstract Burkholderia pseudomallei is a serious, difficult to..

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Substituted aminoacetamides as novel leads for malaria

Neil R. Norcross, Caroline Wilson, Beatriz Baragaña, Irene Hallyburton, Maria Osuna-Cabello, Suzanne Norval, Jennifer Riley, Daniel Fletcher, Robert Sinden, Michael..

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Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

Leah S. Torrie, Fabio Zuccotto, David A. Robinson, David W. Gray, Ian H. Gilbert , Manu De Rycker PLoS ONE..

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Phosphatidylcholine synthesis through cholinephosphate cytidylyltransferase is dispensable in Leishmania major.

Moitra S, Pawlowic MC, Hsu F, Zhang K. Sci Rep [Internet]. 2019;9(1):7602   Abstract Phosphatidylcholine (PC) is a major cell..

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Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Susan Wyllie, Stephen Brand, Michael Thomas, Manu De Rycker, Chun-wa Chung, Imanol Pena, Ryan P. Bingham, Juan A. Bueren-Calabuig, Juan..

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Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Beatriz Baragaña, Barbara Forte, Ryan Choi, Stephen Nakazawa Hewitt, Juan A. Bueren-Calabuig, João Pedro Pisco, Caroline Peet, David M. Dranow,..

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Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity

Fersing C, Basmaciyan L, Boudot C, Pedron J, Hutter S, Cohen A, et al WCAIR contributors : Rachel Milne, Susan..

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Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani.

Victoriano Corpas-Lopez, Sonia Moniz, Michael Thomas, Richard J. Wall, Leah S. Torrie, Dorothea Zander-Dinse, Michele Tinti, Stephen Brand, Laste Stojanovski,..

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Diversity-oriented synthesis of bicyclic fragments containing privileged azines.

Luise N, Wyatt PG Bioorg Med Chem Lett [Internet]. 2019;29(2):248–51 Abstract An innovative and efficient reagent- and scaffold-based diversity oriented..

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