Genome-wide screens connect HD82 loss-of-function to purine analog resistance in African trypanosomes

Anna Trenaman, Michele Tinti , Abdelmadjid Atrih, David Horn Antimicrobrial Chemostherapy mSphere 9:e00363-23. Abstract Nucleoside analogs have been used extensively as..

Short-course combination treatment for experimental chronic Chagas disease

Silvia González, Richard J. Wall, John Thomas, Stephanie Braillard, Gino Brunori, Isabel Camino Díaz, Juan Cantizani, Sandra Carvalho, Pablo Castañeda..

DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1

Stéphanie Braillard , Martine Keenan, Karen J. Breese, Jacob Heppell, Michael Abbott, Rafiqul Islam, David M. Shackleford, Kasiram Katneni, Elly..

An allele-selective inter-chromosomal protein bridge supports monogenic antigen expression in the African trypanosome

Joana R. C. Faria, Michele Tinti, Catarina A. Marques, Martin Zoltner, Harunori Yoshikawa, Mark C. Field & David Horn. Nature..

Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity

Simon R. Green, Caroline Wilson, Thomas C. Eadsforth, Avinash S. Punekar, Fabio K. Tamaki, Gavin Wood, Nicola Caldwell, Barbara Forte,..

RES-Seq—a barcoded library of drug-resistant Leishmania donovani allowing rapid assessment of cross-resistance and relative fitness

Lindsay B. Tulloch, Sandra Carvalho, Marta Lima, Richard J. Wall, Michele Tinti, Erika G. Pinto, Lorna MacLean, Susan Wyllie. Antimicrobial..

Small-Molecule Antibiotic Drug Development: Need and Challenges

Megan Bergkessel, Barbara Forte, and Ian H. Gilbert. ACS Infect. Dis. 2023, 9, 11, 2062–2071 Publication Date:October 11, 2023 https://doi.org/10.1021/acsinfecdis.3c00189 Abstract The..

Characterisation of TcFUT1, a mitochondrial fucosyltransferase from Trypanosoma cruzi

Jose Carlos Paredes Franco, Maria Lucia Sampaio Guther, Marta L. Lima, Michael A.J. Ferguson Molecular and Biochemical Parasitology Vol 256,..

Characterization of the major surface glycoconjugates of Trypanosoma theileri

Rupa Nagar, Isobel Hambleton, Michele Tinti, Mark Carrington, Michael A.J. Ferguson Molecular and Biochemical Parasitology, Vol 256, 111591 Abstract Trypanosoma theileri maintains..

Identification of the glycosylphosphatidylinositol-specific phospholipase A2 (GPI-PLA2) that mediates GPI fatty acid remodeling in Trypanosoma brucei

Zhe Ji , Rupa Nagar, Samuel M. Duncan, Maria Lucia Sampaio Guther, Michael A.J. Ferguson. Journal of Biological Chemistry 299,..

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