Publications

Phosphatidylcholine synthesis through cholinephosphate cytidylyltransferase is dispensable in Leishmania major.

Moitra S, Pawlowic MC, Hsu F, Zhang K. Sci Rep [Internet]. 2019;9(1):7602   Abstract Phosphatidylcholine (PC) is a major cell..

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Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Susan Wyllie, Stephen Brand, Michael Thomas, Manu De Rycker, Chun-wa Chung, Imanol Pena, Ryan P. Bingham, Juan A. Bueren-Calabuig, Juan..

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Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Beatriz Baragaña, Barbara Forte, Ryan Choi, Stephen Nakazawa Hewitt, Juan A. Bueren-Calabuig, João Pedro Pisco, Caroline Peet, David M. Dranow,..

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Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity

Fersing C, Basmaciyan L, Boudot C, Pedron J, Hutter S, Cohen A, et al WCAIR contributors : Rachel Milne, Susan..

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Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani.

Victoriano Corpas-Lopez, Sonia Moniz, Michael Thomas, Richard J. Wall, Leah S. Torrie, Dorothea Zander-Dinse, Michele Tinti, Stephen Brand, Laste Stojanovski,..

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Diversity-oriented synthesis of bicyclic fragments containing privileged azines.

Luise N, Wyatt PG Bioorg Med Chem Lett [Internet]. 2019;29(2):248–51 Abstract An innovative and efficient reagent- and scaffold-based diversity oriented..

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Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei.

Kovářová J, Nagar R, Faria J, Ferguson MAJ, Barrett MP, Horn D. PLOS Pathog. 2018;14(12):e1007475. Bloodstream form African trypanosomes are..

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Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

Michael G. Thomas, Manu De Rycker, Myriam Ajakane, Sébastian Albrecht, Ana Isabel Álvarez-Pedraglio, Markus Boesche, Stephen Brand, Lorna Campbell, Juan..

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2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease.

Thomas MG, De Rycker M, Cotillo Torrejon I, Thomas J, Riley J, Spinks D, et al. Bioorganic & Medicinal Chemistry..

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Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome.

Webster LA, Thomas M, Urbaniak M, Wyllie S, Ong H, Tinti M, et al. ACS Infect. Dis. 2018, 4, 10,..

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