Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei.

Kovářová J, Nagar R, Faria J, Ferguson MAJ, Barrett MP, Horn D. PLOS Pathog. 2018;14(12):e1007475. Bloodstream form African trypanosomes are..

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

Michael G. Thomas, Manu De Rycker, Myriam Ajakane, Sébastian Albrecht, Ana Isabel Álvarez-Pedraglio, Markus Boesche, Stephen Brand, Lorna Campbell, Juan..

2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease.

Thomas MG, De Rycker M, Cotillo Torrejon I, Thomas J, Riley J, Spinks D, et al. Bioorganic & Medicinal Chemistry..

Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome.

Webster LA, Thomas M, Urbaniak M, Wyllie S, Ong H, Tinti M, et al. ACS Infect. Dis. 2018, 4, 10,..

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3.

Wall RJ, Rico E, Lukac I, Zuccotto F, Elg S, Gilbert IH, et al. Proc Natl Acad Sci. 2018;201807915. African..

A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism.

Roberts AJ, Dunne J, Scullion P, Norval S, Fairlamb AH. Biochem J. 2018;BCJ20180232. Trypanosomatid parasites are the infectious agents causing..

Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future.

Smith PW, Zuccotto F, Bates RH, Martinez-Martinez MS, Read KD, Peet C, et al. ACS Infect. Dis. 2018, 4, 10,..

N-glycan microheterogeneity regulates interactions of plasma proteins.

Wu D, Struwe WB, Harvey DJ, Ferguson MAJ, Robinson C V. Proc Natl Acad Sci . 2018; 115 (35) 8763-8768 Altered glycosylation patterns..

Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals.

Wall RJ, Moniz S, Thomas MG, Norval S, Ko E-J, Marco M, et al. Antimicrob Agents Chemother. 2018;62(8):1–15. The lack..

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Susan Wyllie, Michael Thomas, Stephen Patterson, Sabrinia Crouch, Manu De Rycker, Rhiannon Lowe, Stephanie Gresham, Michael D. Urbaniak, Thomas D...

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