Trypanosoma cruzi phosphomannomutase and guanosine diphosphate-mannose pyrophosphorylase ligandability assessment

Filip Zmuda, Sharon M. Shepherd, Michael A. J. Ferguson, David. W. Gray, Leah S. Torrie, Manu De Rycker Antimicrob Agents..

A post-transcriptional respiratome regulon in trypanosomes

Anna Trenaman, Lucy Glover, Sebastian Hutchinson and David Horn Nucleic Acids Res. 2019 Jul 26; 47(13): 7063–7077. Published online 2019..

Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex.

Joana Faria, Lucy Glover, Sebastian Hutchinson, Cordula Boehm, Mark C. Field, David Horn. Nat Commun [Internet]. 2019;10(1):3023. Abstract The largest..

Burkholderia pseudomallei D‐alanine‐D‐alanine ligase; detailed characterisation and assessment of a potential antibiotic drug target

Díaz-Sáez L, Torrie LS, McElroy SP, Gray D, Hunter WN FEBS J [Internet]. 2019;286(22):4509–24 Abstract Burkholderia pseudomallei is a serious, difficult to..

Substituted aminoacetamides as novel leads for malaria

Neil R. Norcross, Caroline Wilson, Beatriz Baragaña, Irene Hallyburton, Maria Osuna-Cabello, Suzanne Norval, Jennifer Riley, Daniel Fletcher, Robert Sinden, Michael..

Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei .

Collett CF, Kitson C, Baker N, Steele-Stallard HB, Santrot M-V, Hutchinson S, Horn D, Alsford S. Antimicrob Agents Chemother [Internet]...

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

Leah S. Torrie, Fabio Zuccotto, David A. Robinson, David W. Gray, Ian H. Gilbert , Manu De Rycker PLoS ONE..

Phosphatidylcholine synthesis through cholinephosphate cytidylyltransferase is dispensable in Leishmania major.

Moitra S, Pawlowic MC, Hsu F, Zhang K. Sci Rep [Internet]. 2019;9(1):7602 Abstract Phosphatidylcholine (PC) is a major cell..

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Susan Wyllie, Stephen Brand, Michael Thomas, Manu De Rycker, Chun-wa Chung, Imanol Pena, Ryan P. Bingham, Juan A. Bueren-Calabuig, Juan..

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Beatriz Baragaña, Barbara Forte, Ryan Choi, Stephen Nakazawa Hewitt, Juan A. Bueren-Calabuig, João Pedro Pisco, Caroline Peet, David M. Dranow,..

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