Publications

Elimination of GPI2 suppresses glycosylphosphatidylinositol GlcNAc transferase activity and alters GPI glycan modification in Trypanosoma brucei

Aurelio Jenni, Sebastian Knüsel, RupaNagar, Mattias Benninger, Robert Häner, Michael A.J.Ferguson, Isabel Roditi, Anant K. Menon, Peter Bütikofer. Journal of..

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Polysomal mRNA Association and Gene Expression in Trypanosoma brucei

Michele Tinti ,  Anna Kelner-Miron,  Lizzie J. Marriott, Michael A.J. Ferguson. Wellcome Open Research 2021 vol 6, Article no. 36...

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Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention

Robert L.Summers, Charisse Flerida A.Pasaje, Joao P.Pisco, Josefine Striepen, Madeline R.Luth, Krittikorn Kumpornsin, Emma F.Carpenter, Justin T.Munro, De Lin, Andrew..

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Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series

Magali Van den Kerkhof, Philippe Leprohon, Dorien Mabille , Sarah Hendrickx, Lindsay B. Tulloch, Richard J. Wall, Susan Wyllie, Eric Chatelain,..

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Expression in Escherichia coli, purification and kinetic characterization of LAPLm, a Leishmania major M17-aminopeptidase

Mirtha Elisa Aguadoa, Maikel González-Matosa, Maikel Izquierdo*, Juan Quintana, Mark C. Field, Jorge González-Bacerioa* Protein Expression and Purification, (2021), 105877,..

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Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation

Karolina Michalska, Robert Jedrzejczak, Jacek Wower, Changsoo Chang, Beatriz Baragaña, Ian H Gilbert, Barbara Forte, Andrzej Joachimiak Nucleic Acids Research,..

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Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial

Luciana S. Paradela, Richard J. Wall, Sandra Carvalho, Giulia Chemi, Victoriano Corpas-Lopez, Eoin Moynihan, Davide Bello, Stephen Patterson, Maria Lucia..

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Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Michael Thomas, Stephen Brand, Manu De Rycker, Fabio Zuccotto, Iva Lukac, Peter G. Dodd, Eun-Jung Ko, Sujatha Manthri, Kate McGonagle,..

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Proteomic identification of the UDP-GlcNAc: PI α1–6 GlcNAc-transferase subunits of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei

Z Ji, M Tinti, MAJ Ferguson PLos One Volume 16, Issue 3 March, March 2021, Article number e0244699 doi 10.1371/journal.pone.0244699..

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Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis

M. Daben J.Libardo, Caroline J.Duncombe, Simon R.Green, Paul G.Wyatt, Stephen Thompson, Peter C. Ray, Thomas R. Ioerger, Sangmi Oh, Michael..

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