Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase

Rachel Milne, Natalie Wiedemar, Victoriano Corpas-Lopez, Eoin Moynihan, Richard J. Wall, Alice Dawson, David A. Robinson, Sharon M. Shepherd, Robert..

Anti-trypanosomatid drug discovery: progress and challenges.

Manu De Rycker, Susan Wyllie, David Horn, Kevin D Read, Ian H Gilbert. Nat Rev Microbiol. 2022 Aug 22:1–16. doi:..

Genetic Transformation of Candida auris via Homology-Directed Repair Using a Standard Lithium Acetate Protocol

Gustavo Bravo Ruiz & Alexander Lorenz Methods in Molecular Biology, vol 2517. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2417-3_8 Abstract Reverse..

High-Throughput Screening Platform To Identify Inhibitors of Protein Synthesis with Potential for the Treatment of Malaria

Fabio Tamaki, Fabio Fisher, Rachel Milne, Fernando Sánchez Román Terán, Natalie Wiedemar, Karolina Wrobel, Darren Edwards, Hella Baumann, Ian H...

Control of Variant Surface Glycoprotein Expression by CFB2 in Trypanosoma brucei and Quantitative Proteomic Connections to Translation and Cytokinesis

Gustavo Bravo Ruiz , Michele Tinti , Melanie Ridgway, David Horn ASM Journals, mSphere, Vol. 7, No. 2, e00069-22 DOI:..

Oligo targeting for profiling drug resistance mutations in the parasitic trypanosomatids

Simone Altmann, Eva Rico, Sandra Carvalho, Melanie Ridgway, Anna Trenaman, Hannah Donnelly, Michele Tinti, Susan Wyllie, David Horn. Nucleic Acids..

Identification and development of a series of disubstituted piperazines for the treatment of Chagas disease.

McGonagle K, Tarver GJ, Cantizani J, Cotillo I, Dodd PG, Ferguson L, Gilbert IH, Marco M, Miles T, Naylor C,..

CRISPR/Cas9-based precision tagging of essential genes in bloodstream form African trypanosomes

Julie Kovářová, Markéta Novotná, Joana Faria, Eva Rico, Catriona Wallace, Martin Zoltner, Mark C. Field, David Horn. Molecular and Biochemical..

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis

Alasdair Smith, Richard J. Wall, Stephen Patterson, Tim Rowan, Eva Rico Vidal, Laste Stojanovski, Margaret Huggett, Shahienaz E. Hampton, Michael..

Visualisation of proteome-wide ordered protein abundances in Trypanosoma brucei

Michele Tinti , Michael A J Ferguson Wellcome Open Res . 2022 Jan 31;7:34. doi: 10.12688/wellcomeopenres.17607.1. eCollection 2022. Abstract Background:..

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