Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes

Joana Faria, Vanessa Luzak, Laura S. M. Müller, Benedikt G. Brink, Sebastian Hutchinson, Lucy Glover, David Horn & T. Nicolai..

Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth

Peter C. Ray, Margaret Huggett, Penelope A. Turner, Malcolm Taylor, Laura A. T. Cleghorn, Julie Early, Anuradha Kumar, Shilah A...

Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site

Vitor Mendes, Simon R Green, Joanna C Evans, Jeannine Hess, Michal Blaszczyk , Christina Spry, Owain Bryant , James Cory-Wright..

Antitubercular 2-Pyrazolylpyrimidinones: Structure–Activity Relationship and Mode-of-Action Studies

Candice Soares de Melo, Vinayak Singh, Alissa Myrick, Sandile B. Simelane, Dale Taylor, Christel Brunschwig, Nina Lawrence, Dirk Schnappinger, Curtis..

Para-site-seeing Catalogue

Floyd, A, Yeoman, H, Southern, J, Dillon, R, Cook, S, Fairlamb, A, Ferguson, M, Horn, D, MacLean, L, Manthri, S,..

Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis

Michael Thomas, De Rycker M, Ajakane M, Crouch S, Campbell L, Daugan A, Fra G, Guerrero C, Mackenzie C, MacLean..

Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties

Fersing C, Boudot C, Paoli-Lombardo R, Primas N, Pinault E, Hutter S, Castera-Ducros C, Kabri Y, Pedron J, Bourgeade-Delmas S,..

Genome-scale functional profiling of cell cycle controls in African trypanosomes

Catarina A. Marques*, Michele Tinti*, Andrew Cassidy, David Horn bioRxiv 2020.07.16.206698; doi: https://doi.org/10.1101/2020.07.16.206698. This article is a preprint and has not been..

Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity

Michael Thomas, De Rycker M, Wall R, Spinks D, Epemolu O, Manthri S, Norval S, Osuna-Cabello M, Patterson S, Riley..

Development of a High-Throughput Screening Assay to Identify Inhibitors of the Major M17-Leucyl Aminopeptidase from Trypanosoma cruzi Using RapidFire Mass Spectrometry

Maikel Izquierdo*, De Lin, Sandra O'Neill, Martin Zoltner, Lauren Webster, Anthony Hope, David W. Gray, Mark C. Field, Jorge González-Bacerio*..

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