Publications

Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.

Prati F, Zuccotto F, Fletcher D, Convery MA, Fernandez-Menendez R, Bates R, et al. ChemMedChem. 2018;13(7):672–7. Our findings reported herein..

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Screening a protein kinase inhibitor library against Plasmodium falciparum.

Hallyburton I, Grimaldi R, Woodland A, Baragaña B, Luksch T, Spinks D, et al. Malar J [Internet]. 2017;16(1):446. Protein kinases..

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Regulation of early endosomes across eukaryotes: Evolution and functional homology of Vps9 proteins.

Herman EK, Ali M, Field MC, Dacks JB. Traffic. 2018;19(7):546–63. Endocytosis is a crucial process in eukaryotic cells. The GTPases..

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Exhaustive sampling of the fragment space associated to a molecule leading to the generation of conserved fragments.

Heikamp K, Zuccotto F, Kiczun M, Ray P, Gilbert IH. Chem Biol Drug Des. 2017;91(3):655–67. The first step in hit..

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Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.

Torrie LS, Brand S, Robinson DA, Ko EJ, Stojanovski L, Simeons FRC, et al. ACS Infect. Dis. 2017, 3, 10,..

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Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi.

Brand S, Ko EJ, Viayna E, Thompson S, Spinks D, Thomas M, et al J Med Chem. 2017;60(17):7284–99. Chagas’ disease,..

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Fragment library design, synthesis and expansion: nurturing a synthesis and training platform.

Ray PC, Kiczun M, Huggett M, Lim A, Prati F, Gilbert IH, et al. Drug Discovery Today. 2017;22(1):43–56. The availability..

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