Publications

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3.

Wall RJ, Rico E, Lukac I, Zuccotto F, Elg S, Gilbert IH, et al. Proc Natl Acad Sci. 2018;201807915. African..

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A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism.

Roberts AJ, Dunne J, Scullion P, Norval S, Fairlamb AH. Biochem J. 2018;BCJ20180232. Trypanosomatid parasites are the infectious agents causing..

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Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future.

Smith PW, Zuccotto F, Bates RH, Martinez-Martinez MS, Read KD, Peet C, et al. ACS Infect. Dis. 2018, 4, 10,..

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N-glycan microheterogeneity regulates interactions of plasma proteins.

Wu D, Struwe WB, Harvey DJ, Ferguson MAJ, Robinson C V. Proc Natl Acad Sci . 2018; 115 (35) 8763-8768 Altered glycosylation patterns..

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Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals.

Wall RJ, Moniz S, Thomas MG, Norval S, Ko E-J, Marco M, et al. Antimicrob Agents Chemother. 2018;62(8):1–15. The lack..

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Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Susan Wyllie, Michael Thomas, Stephen Patterson, Sabrinia Crouch, Manu De Rycker, Rhiannon Lowe, Stephanie Gresham, Michael D. Urbaniak, Thomas D...

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Challenges and recent progress in drug discovery for tropical diseases.

De Rycker M, Baragaña B, Duce SL, Gilbert IH. Nature  559,  498–506 (2018) Infectious tropical diseases have a huge effect in terms of..

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Comparative proteomics of the two T. brucei PABPs suggests that PABP2 controls bulk mRNA.

Zoltner M, Krienitz N, Field MC, Kramer S. PLoS Negl Trop Dis. 2018;12(7). Poly(A)-binding proteins (PABPs) regulate mRNA fate by..

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The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei.

Kelner A, Tinti M, Guther MLS, Foth BJ, Chappell L, Berriman M, et al. PLoS One [Internet]. 2018;13(7):e0201263. Messenger RNA..

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Adaptation and Therapeutic Exploitation of the Plasma Membrane of African Trypanosomes.

Quintana JF, Canavate R, Pino D, Yamada K, Zhang N, Field MC. Genes 2018, 9, 368. African trypanosomes are highly..

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