Protein Crystallographer/ Structural Biologist

Job reference: SLSC0640

Salary: Grade 7 (£32,817-£40,322)

Closing Date: 26 October 2019

The Drug Discovery Unit is seeking an experienced and motivated crystallographer to work on a fragment-based drug discovery project working to generate novel therapeutic agents. This will primarily involve protein crystallisation and co-crystallisation/ soaking. There will also be some elements of assay development and compound design. The successful applicant will be part of an interdisciplinary team including medicinal chemists and cell biologists. The post is available immediately for 2 years.

Requirements

Essential

• A PhD with a large component of protein structural biology using X-ray crystallography or a BSc in Biochemistry or an appropriate degree followed by experience in carrying out X-ray crystallography.
• Hands on experience of protein crystallography with a demonstrable understanding of the range of protein constructs desired/required to support projects.
• Understanding of protein-ligand interactions.
• Experience in obtaining protein:ligand complexes
• Excellent problem solving and creative thinking abilities.
• Good interpersonal skills.
• The ability to work in teams, and to work to timelines and deliver milestones.
• Self-motivated, able to work independently with minimal direction/oversight.

Desirable

• Experience of fragment-based drug discovery.
• Understanding of the drug discovery process

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