Oligo targeting for profiling drug resistance mutations in the parasitic trypanosomatids

Simone Altmann, Eva Rico, Sandra Carvalho, Melanie Ridgway, Anna Trenaman, Hannah Donnelly, Michele Tinti, Susan Wyllie, David Horn. Nucleic Acids..

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CRISPR/Cas9-based precision tagging of essential genes in bloodstream form African trypanosomes

Julie Kovářová, Markéta Novotná, Joana Faria, Eva Rico, Catriona Wallace, Martin Zoltner, Mark C. Field, David Horn. Molecular and Biochemical..

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Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis

Alasdair Smith, Richard J. Wall, Stephen Patterson, Tim Rowan, Eva Rico Vidal, Laste Stojanovski, Margaret Huggett, Shahienaz E. Hampton, Michael..

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Visualisation of proteome-wide ordered protein abundances in Trypanosoma brucei

Michele Tinti , Michael A J Ferguson Wellcome Open Res . 2022 Jan 31;7:34. doi: 10.12688/wellcomeopenres.17607.1. eCollection 2022. Abstract Background:..

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Business Development Manager, Drug Discovery Unit

Job Reference: SLSC1067

Salary:  £53,348 – £60,022

Closing Date: Friday, May 20, 2022

The Drug Discovery Unit (DDU) is looking to appoint a Business Development Manager to support and develop its work. The DDU, established 16 years ago, is a university-based, fully integrated, Biotech-style drug discovery operation of 130 dedicated scientists and a turnover of £12M pa. It has the capabilities to go from hit discovery through to preclinical candidate selection.

The DDU’s remit is to perform early-stage small molecule drug discovery on targets and/or diseases that are under-invested by conventional Pharma/Biotech. We drive translation of innovative research and work with partners across academia and industry to…

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Head of Translational Chemistry, Drug Discovery Unit

Job Reference:  SLSC1071
Closing Date:  Monday, May 16, 2022
Tenured position at Reader/ Professorial Level


The DDU are seeking an experienced medicinal chemist and drug discoverer to be Head of Translational Chemistry. This is an exciting position to develop new small molecule medicines to treat a range of indications, with particular emphases on: infectious diseases affecting Low and Middle Income Countries; and innovative targets in a range of human diseases.This is a substantive leadership post in a highly collaborative environment. The successful applicant will be part of the DDU Senior Leadership Team, which steers and leads the organisation.

Established for 16 years,
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