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Publications

DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Charles E. Mowbray*, Stéphanie Braillard, Paul A. Glossop, Gavin A. Whitlock, Robert T. Jacobs, Jason Speake, Bharathi Pandi, Bakela Nare,..

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Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay

Nina Svensen, Susan Wyllie, David W. Gray, Manu De Rycker PLOS Neglected Tropical Diseases 15(10): e0009870. https://doi.org/10.1371/journal.pntd.0009870 Abstract Chagas disease, caused..

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Genome-scale RNAi screens in African trypanosomes

David Horn Trends in Parasitology 2021. Sep 24;S1471-4922(21)00226-9. doi: 10.1016/j.pt.2021.09.002 Genome-scale genetic screens allow researchers to rapidly identify the genes and..

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A Trypanosoma brucei beta3 glycosyltransferase superfamily gene encodes a beta1-6 GlcNAc-transferase mediating N-glycan and GPI anchor modification

Samuel M. Duncan, Rupa Nagar, Manuela Damerow, Dimtry V. Yashunsky, Benedetta Buzzi, Andrei V. Nikolaev, Michael A.J. Ferguson. Journal of..

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Vacancies

Portfolio Leader: Coronavirus Portfolio in the Drug Discovery Unit

Job Reference: SLSC0980

Salary: Dependent on experience

Closing Date: Friday 7th January

The Drug Discovery Unit (DDU) is passionate about tackling unmet medical need for globally important neglected and emerging infectious diseases (including TB, malaria, coronaviruses), that kill millions of people across the world every year and damage the economies of many countries.

The DDU is a fully integrated “Biotech style” drug discovery organisation with cutting edge facilities. We work to BioPharma philosophy and standards, incorporating dynamic, goal driven project management based on Target Product Profiles and Compound Selection Criteria. Our team of 130 scientists, has extensive experience of all aspects of drug discovery gained within the…

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Medicinal Chemistry Team Leader

Job Reference: SLSC0971
Salary: Grade 9 (£53,348-£60,022)
Closing date: 7th January 2022

The Drug Discovery Unit is passionate about tackling unmet medical need for globally important diseases that kill millions of people across the world every year and damage the economies of many countries.
Established for over 15 years, The Drug Discovery Unit (DDU), School of Life Sciences is a rare, university-based, fully integrated, Biotech-style drug discovery operation with an annual turnover of ~£12M and 130 dedicated scientists, many with a Biotech/Pharma background. The DDU’s remit is to complement Biotech/Pharma activities by tackling early-stage small molecule drug discovery across a range of therapeutic areas. The DDU…

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Research Technician – Compound Management

Job Reference: SLSC0949
Salary:Grade 5 (£22,847 – £26,341)

Closing Date: Wednesday, November 24, 2021

The Drug Discovery Unit is a fully integrated, Biotech-style drug discovery operation with a remit to complement Biotech/Pharma activities by tackling early-stage small molecule drug discovery across a range of therapeutic areas. We work to Biotech philosophy and standards, incorporating dynamic, goal driven project management based on target product profiles and compound selection criteria. Our projects and skillsets cover all aspects of early drug discovery, from hit identification, through lead optimisation to candidate selection. Our experienced team, many of whom have a background in Biotech/Pharma, works in a state-of-the-art building with cutting-edge equipment and automation…

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