Media

Featured Article

Screenshot of David Gray on BBC News

Getting to Know- David Gray

This week (2nd October 2019) we announced that David Gray, Head of Biology for the Drug Discovery Unit, has been promoted to Professor of Translational Biology.  We caught up with David  to find out what set him on the path..

View All Articles

News

David Gray, wearing lab coat and safety glasses, sits at a lab bench.

David Gray promoted to Professor Translational Biology

David Gray has been promoted to Personal Chair. He takes the title of Professor of Translational Biology which is in..

Irene Hallybuton training for the powerlift squat. The photo shows Irene with the weights across her shoulders at the top of the squat. Photo taken by John Post.

Going for Gold

Next week WCAIR malaria researcher Irene Hallyburton is swapping the laboratories of Dundee for the powerlifting arena in St John’s,..

Bloodstream form T. brucei. Image by Lucy Glover from Horn Lab

WCAIR Deputy Director receives £2.1 million Wellcome Investigator award

Wellcome Centre for Anti-Infectives Research Principal Investigator and Deputy Director Professor David Horn will receive a £2.1 million Investigator Award..

View All News

Publications

Trypanosoma cruzi phosphomannomutase and guanosine diphosphate-mannose pyrophosphorylase ligandability assessment

Filip Zmuda, Sharon M. Shepherd, Michael A. J. Ferguson, David. W. Gray, Leah S. Torrie, Manu De Rycker Antimicrob Agents..

A post-transcriptional respiratome regulon in trypanosomes

Anna Trenaman, Lucy Glover, Sebastian Hutchinson and David Horn Nucleic Acids Res. 2019 Jul 26; 47(13): 7063–7077. Published online 2019..

Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex.

Joana Faria, Lucy Glover, Sebastian Hutchinson, Cordula Boehm, Mark C. Field, David Horn. Nat Commun [Internet]. 2019;10(1):3023. Abstract The largest..

Substituted aminoacetamides as novel leads for malaria

Neil R. Norcross, Caroline Wilson, Beatriz Baragaña, Irene Hallyburton, Maria Osuna-Cabello, Suzanne Norval, Jennifer Riley, Daniel Fletcher, Robert Sinden, Michael..

View All Publications

Vacancies

Protein Crystallographer/ Structural Biologist

Job reference: SLSC0640

Salary: Grade 7 (£32,817-£40,322)

Closing Date: 26 October 2019

The Drug Discovery Unit is seeking an experienced and motivated crystallographer to work on a fragment-based drug discovery project working to generate novel therapeutic agents. This will primarily involve protein crystallisation and co-crystallisation/ soaking. There will also be some elements of assay development and compound design. The successful applicant will be part of an interdisciplinary team including medicinal chemists and cell biologists. The post is available immediately for 2 years.

Requirements

Essential

  • A PhD with a large component of protein structural biology using X-ray crystallography or a BSc in Biochemistry or an appropriate degree followed by experience in carrying out X-ray crystallography.
  • Hands on experience of protein crystallography with a demonstrable understanding of the range of protein constructs desired/required to support projects.
  • Understanding of protein-ligand interactions.
  • Experience in obtaining protein:ligand complexes
  • Excellent problem solving and creative thinking abilities.
  • Good interpersonal skills.
  • The ability to work in teams, and to work to timelines and deliver milestones.
  • Self-motivated, able to work independently with minimal direction/oversight.

Desirable

  • Experience of fragment-based drug discovery.
  • Understanding of the drug discovery process

The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.

Apply here