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Publications

Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Michael Thomas, Stephen Brand, Manu De Rycker, Fabio Zuccotto, Iva Lukac, Peter G. Dodd, Eun-Jung Ko, Sujatha Manthri, Kate McGonagle,..

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Proteomic identification of the UDP-GlcNAc: PI α1–6 GlcNAc-transferase subunits of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei

Z Ji, M Tinti, MAJ Ferguson PLos One Volume 16, Issue 3 March, March 2021, Article number e0244699 doi 10.1371/journal.pone.0244699..

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Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis

M. Daben J.Libardo, Caroline J.Duncombe, Simon R.Green, Paul G.Wyatt, Stephen Thompson, Peter C. Ray, Thomas R. Ioerger, Sangmi Oh, Michael..

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Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities.

Lauren B Arendse, Susan Wyllie, Kelly Chibale, Ian H Gilbert. ACS Infect Dis. 2021 Mar 12;7(3):518-534. doi: 10.1021/acsinfecdis.0c00724. Epub 2021..

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Vacancies

DDU Medicinal Chemistry Team leader

Job Reference:  SLSC0878
Salary:  Grade 8 (£41,526 – £49,553)
Closing DateMonday 7th June

The Drug Discovery Unit is a globally acknowledged centre of excellence for drug discovery. The DDU collaborates with partners to translate world-class biology research into novel drug targets and candidate drugs to address unmet medical need across our two areas of activity, Diseases of the Developing World and Innovative Targets Portfolio.We are recruiting for an exceptional individual to join us as a Medicinal Chemistry Team Leader within our Drug Discovery Unit (DDU).

We are seeking…

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Synthetic Medicinal Chemist

Job Reference:  SLSC0874
Salary: Grade 7 (£32,817 – £40,322)
Closing Date: Saturday, June 5, 2021

 

The Drug Discovery Unit are recruiting for a highly motivated medicinal chemist with a BSc or PhD in synthetic organic or medicinal chemistry. You will ideally have subsequent experience in the biopharma industry or related. The post will be primarily laboratory based and of particular interest to talented synthetic chemists and medicinal chemists who want to work in a professional drug discovery environment. The successful candidate will be expected to contribute to drug discovery projects as…

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Analytical Chemistry Analyst / Lab Assistant – Maternity Cover

Job Reference: SLSC0862
Salary: Grade 6 (£26,715 – £32,817)

Closing Date: Wednesday, May 12, 2021

The Drug Discovery Unit are looking for a highly motivated laboratory assistant/analyst with a BSc in Chemistry or another related discipline. With the Analytical/Chemical Inventory Team you will be helping to maintain the analytical chemistry equipment, assist in acquiring data for compound analysis and support compound logistics to ensure compounds and reagents are handled, used and dispensed as efficiently as possible. This is a primarily a hands-on, laboratory-based role which will require first-rate organisational skills and an ability to perform as efficiently as possible.

Your priorities will include:
  • Providing high quality sample analysis…

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