Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series

Magali Van den Kerkhof, Philippe Leprohon, Dorien Mabille , Sarah Hendrickx, Lindsay B. Tulloch, Richard J. Wall, Susan Wyllie, Eric Chatelain,..

Read More

Expression in Escherichia coli, purification and kinetic characterization of LAPLm, a Leishmania major M17-aminopeptidase

Mirtha Elisa Aguadoa, Maikel González-Matosa, Maikel Izquierdo*, Juan Quintana, Mark C. Field, Jorge González-Bacerioa* Protein Expression and Purification, (2021), 105877,..

Read More

Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation

Karolina Michalska, Robert Jedrzejczak, Jacek Wower, Changsoo Chang, Beatriz Baragaña, Ian H Gilbert, Barbara Forte, Andrzej Joachimiak Nucleic Acids Research,..

Read More

Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial

Luciana S. Paradela, Richard J. Wall, Sandra Carvalho, Giulia Chemi, Victoriano Corpas-Lopez, Eoin Moynihan, Davide Bello, Stephen Patterson, Maria Lucia..

Read More
View All Publications


Proteomics Specialist

Job Reference: SLSC0896

Salary: Grade 7 (£32,817 – £40,322)

Closing Date: Wednesday, August 4, 2021

The Mode of Action (MoA) group are seeking to appoint a highly motivated postdoctoral researcher with appropriate skills in proteomics. The MoA group is embedded within the Wellcome Centre for Anti-Infectives Research (WCAIR) and led by Dr Susan Wyllie. The group determines the mechanism of action and molecular targets of anti-parasitic compounds. Specifically, we contribute to the development of drugs for the treatment of malaria, cryptosporidiosis, schistosomiasis, and kinetoplastid-based diseases. We have developed an integrated drug target deconvolution strategy, employing an array of established and new methodologies encompassing high-throughput…

Read More

Medicinal Chemistry Team Leader in the DDU

Ref: SLSC0894

Grade 8: (Grade 8 £41,526-£49,553)

Closing date: 29th August 2021

We are offering an enthusiastic and experienced medicinal chemist the chance to join the dynamic, multidisciplinary Drug Discovery Unit as a team leader.
With your experience gained in the Biotech/Pharma industry or similar, you will lead a talented team of chemists, set and monitor project objectives, and drive interactions between multiple disciplines, and use your experience of multiparameter optimisation to design new molecules to tackle major global diseases.

The Drug Discovery Unit is a fully integrated, Biotech-style drug discovery operation with a remit to complement Biotech/Pharma activities by tackling early-stage small molecule drug discovery across a range…

Read More