The Wellcome Centre for Anti-infectives Research was established in April 2017. We now invite you to share our achievements over the last 3 years. The report highlights key activities across our themes of Research, Training and Public Engagement. The report contains..
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Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series
Magali Van den Kerkhof, Philippe Leprohon, Dorien Mabille , Sarah Hendrickx, Lindsay B. Tulloch, Richard J. Wall, Susan Wyllie, Eric Chatelain,..
Read MoreExpression in Escherichia coli, purification and kinetic characterization of LAPLm, a Leishmania major M17-aminopeptidase
Mirtha Elisa Aguadoa, Maikel González-Matosa, Maikel Izquierdo*, Juan Quintana, Mark C. Field, Jorge González-Bacerioa* Protein Expression and Purification, (2021), 105877,..
Read MoreMycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation
Karolina Michalska, Robert Jedrzejczak, Jacek Wower, Changsoo Chang, Beatriz Baragaña, Ian H Gilbert, Barbara Forte, Andrzej Joachimiak Nucleic Acids Research,..
Read MoreMultiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial
Luciana S. Paradela, Richard J. Wall, Sandra Carvalho, Giulia Chemi, Victoriano Corpas-Lopez, Eoin Moynihan, Davide Bello, Stephen Patterson, Maria Lucia..
Read MoreVacancies
Proteomics Specialist
Job Reference: SLSC0896
Salary: Grade 7 (£32,817 – £40,322)
Closing Date: Wednesday, August 4, 2021
The Mode of Action (MoA) group are seeking to appoint a highly motivated postdoctoral researcher with appropriate skills in proteomics. The MoA group is embedded within the Wellcome Centre for Anti-Infectives Research (WCAIR) and led by Dr Susan Wyllie. The group determines the mechanism of action and molecular targets of anti-parasitic compounds. Specifically, we contribute to the development of drugs for the treatment of malaria, cryptosporidiosis, schistosomiasis, and kinetoplastid-based diseases. We have developed an integrated drug target deconvolution strategy, employing an array of established and new methodologies encompassing high-throughput…
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Medicinal Chemistry Team Leader in the DDU
Ref: SLSC0894
Grade 8: (Grade 8 £41,526-£49,553)
Closing date: 29th August 2021
We are offering an enthusiastic and experienced medicinal chemist the chance to join the dynamic, multidisciplinary Drug Discovery Unit as a team leader.
With your experience gained in the Biotech/Pharma industry or similar, you will lead a talented team of chemists, set and monitor project objectives, and drive interactions between multiple disciplines, and use your experience of multiparameter optimisation to design new molecules to tackle major global diseases.
The Drug Discovery Unit is a fully integrated, Biotech-style drug discovery operation with a remit to complement Biotech/Pharma activities by tackling early-stage small molecule drug discovery across a range…
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