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WCAIR 3 year Report

The Wellcome Centre for Anti-infectives Research was established in April 2017. We now invite you to share our achievements over the last 3 years. The report highlights key activities across our themes of Research, Training and Public Engagement. The report contains..

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News

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Major funding award for international coalition’s disease research

The Drug Discovery Unit (DDU) have been awarded a grant from the Bill & Melinda Gates Foundation of $5M over..

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Fergus Preston wins Young Chemist Award

Fergus Preston, who is undertaking a PhD within the DDU and WCAIR, was one of 10 successful applicants for the..

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Susan Wyllie stands in front of lab equipment

Dr Susan Wyllie completes successful tenure review

Dr Susan Wyllie, Head of the Mode of Action group within WCAIR and Principal Investigator in the School of Life..

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Publications

The role of DMPK science in improving pharmaceutical research and development efficiency

Kit-Kay Mak*, Ola Epemolu , Mallikarjuna Rao Pichika Drug Discovery Today, https://doi.org/10.1016/j.drudis.2021.11.005  Abstract The successful regulatory authority approval rate of..

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DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Charles E. Mowbray*, Stéphanie Braillard, Paul A. Glossop, Gavin A. Whitlock, Robert T. Jacobs, Jason Speake, Bharathi Pandi, Bakela Nare,..

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Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay

Nina Svensen, Susan Wyllie, David W. Gray, Manu De Rycker PLOS Neglected Tropical Diseases 15(10): e0009870. https://doi.org/10.1371/journal.pntd.0009870 Abstract Chagas disease, caused..

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Genome-scale RNAi screens in African trypanosomes

David Horn Trends in Parasitology 2021. Sep 24;S1471-4922(21)00226-9. doi: 10.1016/j.pt.2021.09.002 Genome-scale genetic screens allow researchers to rapidly identify the genes and..

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Vacancies

Junior In Vitro DMPK Scientist

Job Reference: SLSC1013

Salary: Grade 6,  £27,116 – £33,309

Closing Date: Friday, January 28, 2022

The Drug Discovery Unit (DDU) is a fully integrated drug discovery operation based within a world-class Life Sciences research environment. Our remit is to complement BioPharma activities by tackling both neglected disease drug discovery (leishmaniasis, Chagas disease, TB, Cryptosporidiosis and malaria) and validating novel drug targets across a range of therapeutics areas. The DDU works to Biotech style philosophy and standards incorporating, dynamic, goal driven project management based on Target Product Profiles and Compound Selection Criteria. The…

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