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Featured Article

A bright, multicoloured mural on a building

Our biggest science art project yet – literally

We're excited to announce that we've completed our biggest science art project so far - a piece that's 7 storeys tall! We've worked with a whole range of collaborators to bring a dull, blank wall to stunning, scientific life. They..

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News

Trainees on the Practical Aspects Course in Uruguay

Practical Aspects of Drug Discovery Course in Uruguay

We had the pleasure of our first in person course since 2019 last week.  The Practical Aspects of Drug Discovery..

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‘Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs’ published in Nature Communications.

The DDU Tuberculosis team have recently published an article that discusses Lysyl-tRNA synthetase as a new target for urgently needed..

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Head and shoulder shot of Michele Tinti who wears a blue jumper and blue and white checked shirt.

Top 10 place for Michele Tinti in machine learning competition

Dr Michele Tinti recently participated in a biomedicine crowdsourced challenge instigated by DREAM Challenges. Michele was placed 10th out of..

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Publications

CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery

H. J. Benns, M. Storch, J. A. Falco, F. R. Fisher, F. Tamaki, E. Alves, C. J. Wincott, R. Milne,..

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Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs

Simon R. Green, Susan H. Davis, Sebastian Damerow, Curtis A. Engelhart, Michael Mathieson, Beatriz Baragaña, David A. Robinson, Jevgenia Tamjar,..

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Common and unique features of glycosylation and glycosyltransferases in African trypanosomes

Samuel M. Duncan, Michael A.J. Ferguson. Biochem J (2022) 479 (17): 1743–1758. Abstract Eukaryotic protein glycosylation is mediated by glycosyl- and..

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Genome-scale RNA interference profiling of Trypanosoma brucei cell cycle progression defects.

Catarina A. Marques, Melanie Ridgway, Michele Tinti, Andrew Cassidy & David Horn Nat Commun 13, 5326 (2022). https://doi.org/10.1038/s41467-022-33109-y Abstract Trypanosomatids, which..

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Vacancies

Scientific Liaison Manager

Ref: SLSC1137

Salary: £43,414 – £51,805 (Grade 8)

Closing date: 7th November 2022

 

In collaboration with leading Life Sciences partners globally, the DDU has established a portfolio of innovative drug discovery projects to tackle unmet medical need in diseases such cancer, inflammatory diseases, and neurological diseases. Project goals range from identifying lead series demonstrating disease model proof of concept, through to selection of pre-clinical candidates. In addition, we have co-established a national network of collaborators, including the Universities of Oxford and Birmingham, the Francis Crick Institute and the Medicines Discovery Catapult to consolidate UK capabilities and accelerate impact in the development of new therapeutics for age-related diseases.

The DDU…

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