Genetic Manipulation of Cryptosporidium parvum

Sebastian Shaw , Adam Sateriale , Mattie C. Pawlowic, Sumiti Vinayak , Carrie F. Brooks , Jessica H. Byerly , Boris..

Targeting dihydroorotate dehydrogenase (DHODH) for host-directed therapy: Discovery of a novel alkyne-based scaffold inhibitor effective against SARS-CoV-2

Miguel M Vaidergorn, Aline D Purificação , Pedro I P Leite , Sabrina Silva-Mendonça, Wemenes J L Silva, Thiago Dos..

A non-coding role for trypanosome VSG transcripts in allelic exclusion

Douglas O Escrivani, Sebastian Hutchinson, Michele Tinti, Jane E Wright, Catarina A Marques, Joana R C Faria, Anna Trenaman, David Horn Nucleic Acids Research, Volume 53, Issue 19,..

Cryptosporidium oocyst wall proteins are true components of the oocyst wall and COWP8 is not required for parasite transmission

Ross Bacchetti , Sarah Stevens , Leandro Lemgruber , Mariana Azevedo Gonzalez Oliva , Emma M Sands , Konstantinos Alexandrou..

Application of a mouse model humanized for cytochrome P450–mediated drug metabolism to predict drug-drug interactions between a peptide and small molecule drugs

Yury Kapelyukh, Charlotte Gabel-Jensen, Alastaire Kenneth MacLeod, Kevin-Sebastien Daniel Coquelin, Laste Stojanovski, Laura Frame, Amy Tavendale, Colin J. Henderson, Kevin..

Use of P450 Enzymes for Late-Stage Functionalization in Drug Discovery

Vincent Poon, Christopher Bailey, Sandra Carvalho, Stephen Patterson, James W. B. Fyfe, Olga Semenova, Stephen K. Wrigley, Emily Hopkins, Ravi..

Optimization of 2,8-Diaryl-1,5-naphthyridines as Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy

Godwin A. Dziwornu, Donald Seanego, Stephen Fienberg, Venkata S. Sypu, Nicolaas Salomane, Liezl Krugmann, Dale Taylor, Keabetswe Masike, Mathew Njoroge,..

Discovery of a CNS active GSK3 degrader using orthogonally reactive linker screening

Andreas Holmqvist, Nur Mehpare Kocaturk, Christina Duncan, Jennifer Riley, Steven Baginski, Graham Marsh, Joel Cresser-Brown, Hannah Maple, Kristiina Juvonen, Gajanan..

Protocol for a human placental explant model to study acute responses to pathogens

Elias R. Ruiz-Morales, Regina Hoo, Ross F. Waller, Marcus C.S. Lee, David Fernandez-Antoran , Iva Kelava , Roser Vento-Tormo STAR..

Investigation of Ximenia afra Sond. var. afra L. as a source of antiplasmodial and trypanocidal phytochemicals through accelerated bioactivity guided isolation

Wiehana Rudolph, Lauren Webster, Cedric Graebin, Vinesh Maharaj South African Journal of Botany Article 2025 Abstract Ethnopharmacological relevance: Ximenia afra..

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