Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity

Nardella, Florea; Jiang, Tiantianb; Wang, Lushunc;Bohmer, Monica J.a; Chakraborty, Subhojaa; ...Marcus C.S. Lee...Debopma Chakrabati. Cell Chemical Biology Volume 32, Issue..

Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.

Lindsay B. Tulloch, Hugh Tawell, Annie E. Taylor, Marta Lopes Lima , Alice Dawson , Sandra Carvalho, Richard J. Wall,..

Structure–activity relationships of 1,5-dihydro-2H-benzo[b][1,4]diazepine-2,4(3H)-diones as inhibitors of Trypanosoma cruzi

Michael G Thomas, Joanne Dunne, Peter G Dodd, Emiliana D'Oria, Laura Frame, Adolfo Garcia-Perez, Kate McGonagle, Pilar Manzano, Lorna MacLean,..

The Thienopyrimidinone Gamhépathiopine Targets the QO Site of Plasmodium falciparum Cytochrome b

Natalie Wiedemar, Rachel Milne, Sandra Carvalho, Stephen Patterson, Mike Bodkin, Nicolas Masurier, Vincent Lisowski, Nicolas Primas, Pierre Verhaegh, Graeme M...

Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4

Jon Kyle Awalt, Zi Kang Ooi, Trent D. Ashton, Mahta Mansouri, Petar P. S. Calic, Qingmiao Zhou, Santhya Vasanthan, Serena..

Navigating the Landscape of Academic Drug Discovery: An 18-Year Journey

Beatriz Baragaña and Laura A. T. Cleghorn J. Med. Chem. 2025, 68, 8, 7847–7851 A reflection on the 18..

Drug resistance–associated mutations in Plasmodium UBP-1 disrupt its essential deubiquitinating activity

Cameron J. Smith Heledd Eavis, Carla Briggs, Ryan Henrici , Maryia Karpiyevich , Megan R. Ansbro , Johanna Hoshizaki ,..

Identification of a series containing a pentafluorophenyl moiety that targets Pks13 to inhibit growth of Mycobacterium tuberculosis

Simon Green , Justin Harrison, Stephen Thompson, Dinakaran Murugesan, M. Daben J. Libardo, Curtis A. Engelhart, Jaclynn Meshanni, Daniel A...

Use of an extensively humanized mouse model to predict the risk of drug–drug interactions in patients receiving dexamethasone

Jacob George, James D. Chalmers, Kevin-Sebastien Coquelin, Laura Frame, Colin J. Henderson, Yury Kapelyukh, Chim C. Lang, Kevin D. Read,..

Different chemical scaffolds bind to L-phe site in Mycobacterium tuberculosis Phe-tRNA synthetase

Priyanka Gade , Changsoo Chang , Denise S. Pryde , Daniel Fletcher , Sarah Niven , Luma Godoy Magalhaes ,..

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