Protocol for a human placental explant model to study acute responses to pathogens

Elias R. Ruiz-Morales, Regina Hoo, Ross F. Waller, Marcus C.S. Lee, David Fernandez-Antoran , Iva Kelava , Roser Vento-Tormo STAR..

Investigation of Ximenia afra Sond. var. afra L. as a source of antiplasmodial and trypanocidal phytochemicals through accelerated bioactivity guided isolation

Wiehana Rudolph, Lauren Webster, Cedric Graebin, Vinesh Maharaj South African Journal of Botany Article 2025 Abstract Ethnopharmacological relevance: Ximenia afra..

Common Biological Properties of Mycobacterium tuberculosis MmpL3 Inhibitors

Lauren Ames, Renee Allen, Helena I. M. Boshoff, Laura A. T. Cleghorn, Curtis A. Engelhart, Dirk Schnappinger, Tanya Parish* ACS..

Biophysical analysis of an oligomerization-attenuated variant of the Leishmania donovani dynamin-1-like protein

Ellen Wuyts , Ramasubramanian Sundaramoorthy , Lindsay Tulloch , Pieter Monsieurs , Thomas C Eadsforth , Isabel Pintelon , Jean-Pierre..

Decoding efficacy and resistance space at a drug binding site

Simone Altmann, Cesar Mendoza-Martinez, Melanie Ridgway, Michele Tinti, Jagmohan S. Saini, Peter E. G. F. Ibrahim, Michael Thomas, Manu De Rycker, Michael J. Bodkin, David Horn bioRxiv 2025.07.25.666894; doi: https://doi.org/10.1101/2025.07.25.666894 This article is a preprint and has not been certified by peer..

Overcoming a false-positive mechanism in RapidFire MRM-based high throughput screening

De Lin, Lesley-Anne Pearson, Shamshad Ahmad, Sandra O'Neill, John Post, Colin Robinson, Duncan E Scott, Ian H Gilbert. SLAS Discovery..

Comparative metabolism of conjugated and unconjugated pterins in Crithidia, Leishmania and African trypanosomes.

Han B. Ong, Susan Wyllie, Alan H. Fairlamb Neglected Tropical Diseases 19(7): e0013332 Abstract Mammalian cells synthesise tetrahydrobiopterin de novo,..

Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1

William Nguyen, Coralie Boulet, Madeline G. Dans, Katie Loi, Kate E. Jarman, Claudia B. G. Barnes, Tomas Yeo, Tanaya Sheth,..

Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity

Nardella, Florea; Jiang, Tiantianb; Wang, Lushunc;Bohmer, Monica J.a; Chakraborty, Subhojaa; ...Marcus C.S. Lee...Debopma Chakrabati. Cell Chemical Biology Volume 32, Issue..

Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.

Lindsay B. Tulloch, Hugh Tawell, Annie E. Taylor, Marta Lopes Lima , Alice Dawson , Sandra Carvalho, Richard J. Wall,..

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