Biophysical analysis of an oligomerization-attenuated variant of the Leishmania donovani dynamin-1-like protein

Ellen Wuyts , Ramasubramanian Sundaramoorthy , Lindsay Tulloch , Pieter Monsieurs , Thomas C Eadsforth , Isabel Pintelon , Jean-Pierre..

Decoding efficacy and resistance space at a drug binding site

Simone Altmann, Cesar Mendoza-Martinez, Melanie Ridgway, Michele Tinti, Jagmohan S. Saini, Peter E. G. F. Ibrahim, Michael Thomas, Manu De Rycker, Michael J. Bodkin, David Horn bioRxiv 2025.07.25.666894; doi: https://doi.org/10.1101/2025.07.25.666894 This article is a preprint and has not been certified by peer..

Overcoming a false-positive mechanism in RapidFire MRM-based high throughput screening

De Lin, Lesley-Anne Pearson, Shamshad Ahmad, Sandra O'Neill, John Post, Colin Robinson, Duncan E Scott, Ian H Gilbert. SLAS Discovery..

Comparative metabolism of conjugated and unconjugated pterins in Crithidia, Leishmania and African trypanosomes.

Han B. Ong, Susan Wyllie, Alan H. Fairlamb Neglected Tropical Diseases 19(7): e0013332 Abstract Mammalian cells synthesise tetrahydrobiopterin de novo,..

Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity

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Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.

Lindsay B. Tulloch, Hugh Tawell, Annie E. Taylor, Marta Lopes Lima , Alice Dawson , Sandra Carvalho, Richard J. Wall,..

Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes

Markéta Novotná , Michele Tinti , Joana R C Faria , David Horn Nature Communications. 2025 Jul 4;16(1):6194. doi: 10.1038/s41467-025-61480-z..

Structure–activity relationships of 1,5-dihydro-2H-benzo[b][1,4]diazepine-2,4(3H)-diones as inhibitors of Trypanosoma cruzi

Michael G Thomas, Joanne Dunne, Peter G Dodd, Emiliana D'Oria, Laura Frame, Adolfo Garcia-Perez, Kate McGonagle, Pilar Manzano, Lorna MacLean,..

The Thienopyrimidinone Gamhépathiopine Targets the QO Site of Plasmodium falciparum Cytochrome b

Natalie Wiedemar, Rachel Milne, Sandra Carvalho, Stephen Patterson, Mike Bodkin, Nicolas Masurier, Vincent Lisowski, Nicolas Primas, Pierre Verhaegh, Graeme M...

Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4

Jon Kyle Awalt, Zi Kang Ooi, Trent D. Ashton, Mahta Mansouri, Petar P. S. Calic, Qingmiao Zhou, Santhya Vasanthan, Serena..

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