Publications

Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4

Jon Kyle Awalt, Zi Kang Ooi, Trent D. Ashton, Mahta Mansouri, Petar P. S. Calic, Qingmiao Zhou, Santhya Vasanthan, Serena..

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Navigating the Landscape of Academic Drug Discovery: An 18-Year Journey

Beatriz Baragaña and Laura A. T. Cleghorn J. Med. Chem. 2025, 68, 8, 7847–7851   A reflection on the 18..

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Drug resistance–associated mutations in Plasmodium UBP-1 disrupt its essential deubiquitinating activity

Cameron J. Smith Heledd Eavis, Carla Briggs, Ryan Henrici , Maryia Karpiyevich , Megan R. Ansbro , Johanna Hoshizaki ,..

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Use of an extensively humanized mouse model to predict the risk of drug–drug interactions in patients receiving dexamethasone

Jacob George, James D. Chalmers, Kevin-Sebastien Coquelin, Laura Frame, Colin J. Henderson, Yury Kapelyukh, Chim C. Lang,   Kevin D. Read,..

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Different chemical scaffolds bind to L-phe site in Mycobacterium tuberculosis Phe-tRNA synthetase

Priyanka Gade , Changsoo Chang , Denise S. Pryde , Daniel Fletcher , Sarah Niven , Luma Godoy Magalhaes ,..

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Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity

Mukul Rawat, Gilda Padalino, Edem Adika, John Okombo, Tomas Yeo, Andrea Brancale, David A. Fidock, Karl F. Hoffmann, Marcus C...

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The Trypanosoma cruzi cell atlas; a single-cell resource for understanding parasite population heterogeneity and differentiation

Ross Laidlaw, Marta Garcia Sanchez,  Juliana Da Silva Pacheco,  Luciana De Sousa Paradela, Thomas D Otto,  Manu De Rycker bioRxiv 2024.10.01.616042; doi: https://doi.org/10.1101/2024.10.01.616042..

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Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors

Thomas C. Eadsforth , Leah S. Torrie, Paul Rowland*, Emma V. Edgar*, Lorna M. MacLean, Christy Paterson, David A. Robinson,..

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Use of Crithidia fasciculata extract for the facile enzymatic synthesis of GDP-L-[3H]Fucose

Jose Carlos Paredes Franco , Maria Lucia Sampaio Güther , Michael A J Ferguson Glycobiology, Volume 35, Issue 2, February 2025, cwae097 Abstract For..

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SPPIRIT: a network connecting Scottish early-career researchers in parasitology

Rebecca C.S. Edgar, Jack Hanna, Markéta Novotná, Marta Campillo Poveda, Mukul Rawat, Shikha Shikha, Frank Venter, Melanie C. Ridgway. Trends..

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