A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants

Letícia Tiburcio Ferreira, Gustavo Capatti Cassiano, Luis Carlos Salazar Alvarez, John Okombo, Juliana Calit, Diana Fontinha, Eva Gil-Iturbe, Rachael Coyle,..

Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against Mycobacterium abscessus and Mycobacterium avium, Two Emerging Human Pathogens

Matheus Andrade Meirelles, Vitor M. Almeida, Jaryd R. Sullivan, Ian de Toledo, Caio Vinicius dos Reis, Micael Rodrigues Cunha, Rachel..

Post-transcriptional reprogramming by thousands of mRNA untranslated regions in trypanosomes

Anna Trenaman, Michele Tinti, Richard J. Wall & David Horn Nat Commun 15, 8113 (2024). Abstract Although genome-wide polycistronic transcription places..

ResMAP-a saturation mutagenesis platform enabling parallel profiling of target-specific resistance-conferring mutations in Plasmodium

Richard J Wall , Stuart A MacGowan , Irene Hallyburton , Aisha J Syed , Sowmya Ajay Castro , Gourav..

The major surface protein of malaria sporozoites is GPI-anchored to the plasma membrane

Rupa Nagar, Stefano S Garcia Castillo, Maria Pinzon-Ortiz, Sharon Patray, Alida Coppi, Sachie Kanatani, Robert L Moritz, Kristian E Swearingen,..

A proposed pathway from D-glucose to D-arabinose in eukaryotes

Elda Iljazi, Rupa Nagar, Sabine Kuettel, Kieron Lucas, Arthur Crossman, Marie-Ange Badet-Denisot, Ronald W. Woodard, Michael A.J. Ferguson. Journal of..

Superior Anticancer and Antifungal Activities of New Sulfanyl-Substituted Niclosamide Derivatives

Ma, Jingyi, Dileepkumar Veeragoni, Hindole Ghosh, Nicole Mutter, Gisele Barbosa [1], Lauren Webster, Rainer Schobert, Wendy van de Sande, Prasad..

Generation of a bloodstream form Trypanosoma brucei double glycosyltransferase null mutant competent in receptor-mediated endocytosis of transferrin

Samuel M. Duncan, Carla Gilabert Carbajo, Rupa Nagar, Qi Zhong, Conor Breen, Michael A. J. Ferguson ,Calvin Tiengwe PLOS Pathogens..

Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1

Lindsay B. Tulloch, Michele Tinti, Richard J. Wall, Stefan K. Weidt, Victoriano Corpas- Lopez, Gourav Dey, Terry K. Smith, Alan..

Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential

Omar Khoumeri, Sébastien Hutter, Nicolas Primas, Caroline Castera-Ducros, Sandra Carvalho, Susan Wyllie, Mohamed Lotfi Efrit, Dimitri Fayolle, Marc Since, Patrice..

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