Publications

Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series

Magali Van den Kerkhof, Philippe Leprohon, Dorien Mabille , Sarah Hendrickx, Lindsay B. Tulloch, Richard J. Wall, Susan Wyllie, Eric Chatelain,..

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Expression in Escherichia coli, purification and kinetic characterization of LAPLm, a Leishmania major M17-aminopeptidase

Mirtha Elisa Aguadoa, Maikel González-Matosa, Maikel Izquierdo*, Juan Quintana, Mark C. Field, Jorge González-Bacerioa* Protein Expression and Purification, (2021), 105877,..

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Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation

Karolina Michalska, Robert Jedrzejczak, Jacek Wower, Changsoo Chang, Beatriz Baragaña, Ian H Gilbert, Barbara Forte, Andrzej Joachimiak Nucleic Acids Research,..

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Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial

Luciana S. Paradela, Richard J. Wall, Sandra Carvalho, Giulia Chemi, Victoriano Corpas-Lopez, Eoin Moynihan, Davide Bello, Stephen Patterson, Maria Lucia..

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Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Michael Thomas, Stephen Brand, Manu De Rycker, Fabio Zuccotto, Iva Lukac, Peter G. Dodd, Eun-Jung Ko, Sujatha Manthri, Kate McGonagle,..

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Proteomic identification of the UDP-GlcNAc: PI α1–6 GlcNAc-transferase subunits of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei

Z Ji, M Tinti, MAJ Ferguson PLos One Volume 16, Issue 3 March, March 2021, Article number e0244699 doi 10.1371/journal.pone.0244699..

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Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis

M. Daben J.Libardo, Caroline J.Duncombe, Simon R.Green, Paul G.Wyatt, Stephen Thompson, Peter C. Ray, Thomas R. Ioerger, Sangmi Oh, Michael..

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Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities.

Lauren B Arendse, Susan Wyllie, Kelly Chibale, Ian H Gilbert. ACS Infect Dis. 2021 Mar 12;7(3):518-534. doi: 10.1021/acsinfecdis.0c00724. Epub 2021..

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Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry

Lesley-Anne Pearson, Charlotte J Green, De Lin, Alain-Pierre Petit, David W Gray, Victoria H Cowling, Euan A F Fordyce. SLAS..

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De Novo Synthesis of Phosphatidylcholine Is Essential for the Promastigote But Not Amastigote Stage in Leishmania major

Samrat Moitra, Somrita Basu, Mattie Pawlowic, Fong-fu Hsu and Kai Zhang Front. Cell. Infect. Microbiol., 12 March 2021 | https://doi.org/10.3389/fcimb.2021.647870..

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