Publications

The role of DMPK science in improving pharmaceutical research and development efficiency

Kit-Kay Mak*, Ola Epemolu , Mallikarjuna Rao Pichika Drug Discovery Today, https://doi.org/10.1016/j.drudis.2021.11.005  Abstract The successful regulatory authority approval rate of..

Read More

DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Charles E. Mowbray*, Stéphanie Braillard, Paul A. Glossop, Gavin A. Whitlock, Robert T. Jacobs, Jason Speake, Bharathi Pandi, Bakela Nare,..

Read More

Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay

Nina Svensen, Susan Wyllie, David W. Gray, Manu De Rycker PLOS Neglected Tropical Diseases 15(10): e0009870. https://doi.org/10.1371/journal.pntd.0009870 Abstract Chagas disease, caused..

Read More

Genome-scale RNAi screens in African trypanosomes

David Horn Trends in Parasitology 2021. Sep 24;S1471-4922(21)00226-9. doi: 10.1016/j.pt.2021.09.002 Genome-scale genetic screens allow researchers to rapidly identify the genes and..

Read More

A Trypanosoma brucei beta3 glycosyltransferase superfamily gene encodes a beta1-6 GlcNAc-transferase mediating N-glycan and GPI anchor modification

Samuel M. Duncan, Rupa Nagar, Manuela Damerow, Dimtry V. Yashunsky, Benedetta Buzzi, Andrei V. Nikolaev, Michael A.J. Ferguson. Journal of..

Read More

Synthesis of a Series of Diaminoindoles

James S. Martin, Claire J. Mackenzie, and Ian H. Gilbert J. Org. Chem. 2021, 86, 17, 11333–11340 , https://doi.org/10.1021/acs.joc.1c00652 Abstract..

Read More

Ligand binding: evaluating the contribution of the water molecules network using the Fragment Molecular Orbital method

Iva Lukac, Paul G. Wyatt, Ian H. Gilbert, Fabio Zuccotto J Comput Aided Mol Des (2021). https://doi.org/10.1007/s10822-021-00416-3 Abstract Water molecules play..

Read More

Utilizing thermal proteome profiling to identify the molecular targets of anti-leishmanial compounds

Victoriano Corpas-Lopez, Susan Wyllie. STAR Protocols,2021, Volume 2, Issue 3, 100704  doi.org/10.1016/j.xpro.2021.100704. Abstract Here, we detail our optimized protocol for..

Read More

An essential, kinetoplastid-specific GDP-Fuc: β-D-Gal α-1,2-fucosyltransferase is located in the mitochondrion of Trypanosoma brucei

Giulia Bandini, Sebastian Damerow, Maria Lucia Sempaio Güther, Hongjie Guo, Angela Mehlert, Jose Carlos Paredes Franco, Stephen Beverley, Michael A..

Read More

Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity

Juliana da Silva Pacheco, Débora de Souza Costa, Edézio Ferreira Cunha-Júnior, Valter Viana Andrade-Neto, Alan H. Fairlamb, Susan Wyllie, Marília..

Read More