Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay

Nina Svensen, Susan Wyllie, David W. Gray, Manu De Rycker PLOS Neglected Tropical Diseases 15(10): e0009870. https://doi.org/10.1371/journal.pntd.0009870 Abstract Chagas disease, caused..

Genome-scale RNAi screens in African trypanosomes

David Horn Trends in Parasitology 2021. Sep 24;S1471-4922(21)00226-9. doi: 10.1016/j.pt.2021.09.002 Genome-scale genetic screens allow researchers to rapidly identify the genes and..

A Trypanosoma brucei beta3 glycosyltransferase superfamily gene encodes a beta1-6 GlcNAc-transferase mediating N-glycan and GPI anchor modification

Samuel M. Duncan, Rupa Nagar, Manuela Damerow, Dimtry V. Yashunsky, Benedetta Buzzi, Andrei V. Nikolaev, Michael A.J. Ferguson. Journal of..

Synthesis of a Series of Diaminoindoles

James S. Martin, Claire J. Mackenzie, and Ian H. Gilbert J. Org. Chem. 2021, 86, 17, 11333–11340 , https://doi.org/10.1021/acs.joc.1c00652 Abstract..

Ligand binding: evaluating the contribution of the water molecules network using the Fragment Molecular Orbital method

Iva Lukac, Paul G. Wyatt, Ian H. Gilbert, Fabio Zuccotto J Comput Aided Mol Des (2021). https://doi.org/10.1007/s10822-021-00416-3 Abstract Water molecules play..

Utilizing thermal proteome profiling to identify the molecular targets of anti-leishmanial compounds

Victoriano Corpas-Lopez, Susan Wyllie. STAR Protocols,2021, Volume 2, Issue 3, 100704 doi.org/10.1016/j.xpro.2021.100704. Abstract Here, we detail our optimized protocol for..

An essential, kinetoplastid-specific GDP-Fuc: β-D-Gal α-1,2-fucosyltransferase is located in the mitochondrion of Trypanosoma brucei

Giulia Bandini, Sebastian Damerow, Maria Lucia Sempaio Güther, Hongjie Guo, Angela Mehlert, Jose Carlos Paredes Franco, Stephen Beverley, Michael A..

Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity

Juliana da Silva Pacheco, Débora de Souza Costa, Edézio Ferreira Cunha-Júnior, Valter Viana Andrade-Neto, Alan H. Fairlamb, Susan Wyllie, Marília..

Automated Phylogenetic Analysis Using Best Reciprocal BLAST

Erin R Butterfield , James C Abbott , Mark C Field In: de Pablos L.M., Sotillo J. (eds) Parasite Genomics...

Elimination of GPI2 suppresses glycosylphosphatidylinositol GlcNAc transferase activity and alters GPI glycan modification in Trypanosoma brucei

Aurelio Jenni, Sebastian Knüsel, RupaNagar, Mattias Benninger, Robert Häner, Michael A.J.Ferguson, Isabel Roditi, Anant K. Menon, Peter Bütikofer. Journal of..

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