SophosQM: Accurate Binding Affinity Prediction in Compound Optimization

Riccardo Guareschi, Iva Lukac, Ian H. Gilbert, and Fabio Zuccotto ACS Omega 2023, 8, 17, 15083–15098 Abstract The optimization of compounds’..

Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022

Nicola Caldwell, Rana Afshar, Beatriz Baragaña, Amaya L. Bustinduy, Conor R. Caffrey, James J. Collins, Daniela Fusco, Amadou Garba, Mark..

Design and Synthesis of Covalent Inhibitors of FabA

James S. Martin, Claire J. Mackenzie, De Lin, Nadine Homeyer, David W. Gray, Fabio Zuccotto, and Ian H. Gilbert ACS..

Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation

Selina Bopp, Charisse Flerida A. Pasaje, Robert L. Summers, Pamela Magistrado-Coxen, Kyra A. Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok,..

Assessment of the drugability of initial malaria infection through miniaturized sporozoite assays and high-throughput screening

Marie Miglianico, Judith M. Bolscher, Martijn W. Vos, Karin J. M. Koolen, Marloes de Bruijni, Deeya S. Rajagopal, Emily Chen,..

The role of invariant surface glycoprotein 75 in xenobiotic acquisition by African trypanosomes

Alexandr Makarov, Jakub Began, Ileana Corvo Mautone, Erika Pinto, Liam Ferguson, Martin Zoltner, Sebastian Zoll and Mark C. Field. Microbial..

Peptidyl tRNA Hydrolase Is Required for Robust Prolyl-tRNA Turnover in Mycobacterium tuberculosis

Francesca G. Tomasi, Jessica T. P. Schweber, Satoshi Kimura, Junhao Zhu, Laura A. T. Cleghorn, Susan H. Davis, Simon R...

Impact of inherent biases built into proteomic techniques: Proximity labeling and affinity capture compared

Claudia Maria do Nascimento Moreira, Cristina D. Kelemen, Samson O. Obado , Farnaz Zahedifard , Ning Zhang , Fabiola B...

Ethanolaminephosphate cytidyltransferase is essential for survival, lipid homeostasis and stress tolerance in Leishmania major

Somrita Basu, Mattie Pawlowic, Fong-Fu Hsu, Geoff Thomas, Kai Zhang. bioRxiv 2023.01.10.523530; doi: https://doi.org/10.1101/2023.01.10.523530 This article is a preprint and has not been..

Chemical pulldown combined with mass spectrometry to identify the molecular targets of antimalarials in cell-free lysates

Robert J Smith , Rachel Milne , Victoriano Corpas Lopez , Natalie Wiedemar , Gourav Dey , Aisha J Syed..

1 2 3 … 13 Next »

Publications