Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors

Thomas C. Eadsforth , Leah S. Torrie, Paul Rowland*, Emma V. Edgar*, Lorna M. MacLean, Christy Paterson, David A. Robinson,..

SPPIRIT: a network connecting Scottish early-career researchers in parasitology

Rebecca C.S. Edgar, Jack Hanna, Markéta Novotná, Marta Campillo Poveda, Mukul Rawat, Shikha Shikha, Frank Venter, Melanie C. Ridgway. Trends..

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance

Madeline R. Luth, Karla P. Godinez-Macias , Daisy Chen , John Okombo, Vandana Thathy , Xiu Cheng, Sindhu Daggupati ,..

A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants

Letícia Tiburcio Ferreira, Gustavo Capatti Cassiano, Luis Carlos Salazar Alvarez, John Okombo, Juliana Calit, Diana Fontinha, Eva Gil-Iturbe, Rachael Coyle,..

Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against Mycobacterium abscessus and Mycobacterium avium, Two Emerging Human Pathogens

Matheus Andrade Meirelles, Vitor M. Almeida, Jaryd R. Sullivan, Ian de Toledo, Caio Vinicius dos Reis, Micael Rodrigues Cunha, Rachel..

Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy

Nicola Caldwell , Caroline Peet, Peter Miller, Beatrice L. Colon, Malcolm G. Taylor, Mattia Cocco, Alice Dawson , Iva Lukac,..

Post-transcriptional reprogramming by thousands of mRNA untranslated regions in trypanosomes

Anna Trenaman, Michele Tinti, Richard J. Wall & David Horn Nat Commun 15, 8113 (2024). Abstract Although genome-wide polycistronic transcription places..

ResMAP-a saturation mutagenesis platform enabling parallel profiling of target-specific resistance-conferring mutations in Plasmodium

Richard J Wall , Stuart A MacGowan , Irene Hallyburton , Aisha J Syed , Sowmya Ajay Castro , Gourav..

The major surface protein of malaria sporozoites is GPI-anchored to the plasma membrane

Rupa Nagar, Stefano S Garcia Castillo, Maria Pinzon-Ortiz, Sharon Patray, Alida Coppi, Sachie Kanatani, Robert L Moritz, Kristian E Swearingen,..

A proposed pathway from D-glucose to D-arabinose in eukaryotes

Elda Iljazi, Rupa Nagar, Sabine Kuettel, Kieron Lucas, Arthur Crossman, Marie-Ange Badet-Denisot, Ronald W. Woodard, Michael A.J. Ferguson. Journal of..

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