Publications

Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Michael Thomas, Stephen Brand, Manu De Rycker, Fabio Zuccotto, Iva Lukac, Peter G. Dodd, Eun-Jung Ko, Sujatha Manthri, Kate McGonagle,..

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Proteomic identification of the UDP-GlcNAc: PI α1–6 GlcNAc-transferase subunits of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei

Z Ji, M Tinti, MAJ Ferguson PLos One Volume 16, Issue 3 March, March 2021, Article number e0244699 doi 10.1371/journal.pone.0244699..

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Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis

M. Daben J.Libardo, Caroline J.Duncombe, Simon R.Green, Paul G.Wyatt, Stephen Thompson, Peter C. Ray, Thomas R. Ioerger, Sangmi Oh, Michael..

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Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities.

Lauren B Arendse, Susan Wyllie, Kelly Chibale, Ian H Gilbert. ACS Infect Dis. 2021 Mar 12;7(3):518-534. doi: 10.1021/acsinfecdis.0c00724. Epub 2021..

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Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry

Lesley-Anne Pearson, Charlotte J Green, De Lin, Alain-Pierre Petit, David W Gray, Victoria H Cowling, Euan A F Fordyce. SLAS..

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Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial.

Luciana S Paradela, Richard J Wall, Sandra Carvalho, Giulia Chemi, Victoriano Corpas-Lopez, Eoin Moynihan, Davide Bello, Stephen Patterson, Maria Lucia..

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MalDA, Accelerating Malaria

Tuo Yang, Sabine Ottilie, Eva S Istvan, Karla P Godinez-Macias, Amanda K Lukens, Beatriz Baragaña, Brice Campo, Chris Walpole, Jacquin..

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A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research

Suzannah J. Rihn , Andres Merits , Siddharth Bakshi , Matthew L. Turnbull , Arthur Wickenhagen , Akira J. T...

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Structure-Activity Relationships of Pyrazolo[1,5- a]pyrimidin-7(4 H)-ones as Antitubercular Agents

Sangmi Oh, M Daben J Libardo, Shaik Azeeza, Gary T Pauly, Jose Santinni O Roma, Andaleeb Sajid, Yoshitaka Tateishi, Caroline..

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Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes

Joana Faria, Vanessa Luzak, Laura S. M. Müller, Benedikt G. Brink, Sebastian Hutchinson, Lucy Glover, David Horn & T. Nicolai..

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