Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes

Joana Faria, Vanessa Luzak, Laura S. M. Müller, Benedikt G. Brink, Sebastian Hutchinson, Lucy Glover, David Horn & T. Nicolai..

Para-site-seeing Catalogue

Floyd, A, Yeoman, H, Southern, J, Dillon, R, Cook, S, Fairlamb, A, Ferguson, M, Horn, D, MacLean, L, Manthri, S,..

Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis

Michael Thomas, De Rycker M, Ajakane M, Crouch S, Campbell L, Daugan A, Fra G, Guerrero C, Mackenzie C, MacLean..

Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties

Fersing C, Boudot C, Paoli-Lombardo R, Primas N, Pinault E, Hutter S, Castera-Ducros C, Kabri Y, Pedron J, Bourgeade-Delmas S,..

Genome-scale functional profiling of cell cycle controls in African trypanosomes

Catarina A. Marques*, Michele Tinti*, Andrew Cassidy, David Horn bioRxiv 2020.07.16.206698; doi: https://doi.org/10.1101/2020.07.16.206698. This article is a preprint and has not been..

Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity

Michael Thomas, De Rycker M, Wall R, Spinks D, Epemolu O, Manthri S, Norval S, Osuna-Cabello M, Patterson S, Riley..

Development of a High-Throughput Screening Assay to Identify Inhibitors of the Major M17-Leucyl Aminopeptidase from Trypanosoma cruzi Using RapidFire Mass Spectrometry

Maikel Izquierdo*, De Lin, Sandra O'Neill, Martin Zoltner, Lauren Webster, Anthony Hope, David W. Gray, Mark C. Field, Jorge González-Bacerio*..

Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes

Martin Zoltner, Gustavo D Campagnaro, Gergana Taleva, Alana Burrell, Michela Cerone, Ka-Fai Leung, Fiona Achcar, David Horn, Sue Vaughan, Catarina..

Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase

Leah S. Torrie, David A. Robinson, Michael Thomas, Judith V Hobrath, Sharon M Shepherd, John M. Post, Eun-Jung Ko, Rafael..

Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease

Justin R. Harrison, Sandipan Sarkar, Shahienaz Hampton, Jennifer Riley, Laste Stojanovski, Christer Sahlberg, Pia Appelqvist, Jessey Erath, Vinodhini Mathan, Ana..

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