Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors

Michael G Thomas , Kate McGonagle , Paul Rowland , David A Robinson , Peter G Dodd , Isabel Camino-Díaz..

Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in Trypanosoma brucei

Bachmaier, Sabine, Gould, Matthew K., Polatoglou, Eleni, Omelianczyk, Radoslaw, Brennand, Ana E., Aloraini, Maha A., Munday, Jane C., Horn, David,..

Bespoke Drug Discovery Training for Low-Middle Income Countries

Lauren A. Webster, Susan J. Farrell, Ian H. Gilbert, and Kevin D. Read ACS Med. Chem. Lett. 2023, XXXX, XXX, XXX-XXX Publication..

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues

Laura A. T. Cleghorn, Richard J. Wall, Sébastien Albrecht, Stuart A. MacGowan, Suzanne Norval, Manu De Rycker, Andrew Woodland, Daniel..

The critical role of mode of action studies in kinetoplastid drug discovery

Alan H. Fairlamb and Susan Wyllie Front. Drug Discov., 10 May 2023 Sec. Anti-Infective Agents, Volume 3 - 2023 Understanding..

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum

Krittikorn Kümpornsin, Theerarat Kochakarn, Tomas Yeo, John Okombo, Madeline R. Luth, Johanna Hoshizaki, Mukul Rawat, Richard D. Pearson, Kyra A...

SophosQM: Accurate Binding Affinity Prediction in Compound Optimization

Riccardo Guareschi, Iva Lukac, Ian H. Gilbert, and Fabio Zuccotto ACS Omega 2023, 8, 17, 15083–15098 Abstract The optimization of compounds’..

Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022

Nicola Caldwell, Rana Afshar, Beatriz Baragaña, Amaya L. Bustinduy, Conor R. Caffrey, James J. Collins, Daniela Fusco, Amadou Garba, Mark..

Design and Synthesis of Covalent Inhibitors of FabA

James S. Martin, Claire J. Mackenzie, De Lin, Nadine Homeyer, David W. Gray, Fabio Zuccotto, and Ian H. Gilbert ACS..

Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation

Selina Bopp, Charisse Flerida A. Pasaje, Robert L. Summers, Pamela Magistrado-Coxen, Kyra A. Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok,..

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