Chemical pulldown combined with mass spectrometry to identify the molecular targets of antimalarials in cell-free lysates

Robert J Smith , Rachel Milne , Victoriano Corpas Lopez , Natalie Wiedemar , Gourav Dey , Aisha J Syed..

Antileishmanial Activities of (Z)-2-(Nitroimidazolylmethylene)-3(2H)-Benzofuranones: Synthesis, In Vitro Assessment, and Bioactivation by NTR 1 and 2

Latifeh Navidpour, Marta Lopes Lima, Rachel Milne, Susan Wyllie, Narges Hadj-esfandiari, Muhammad Iqbal Choudhary, Samreen Khan, Sammer Yousuf Antimicrobial Agents..

CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery

H. J. Benns, M. Storch, J. A. Falco, F. R. Fisher, F. Tamaki, E. Alves, C. J. Wincott, R. Milne,..

Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs

Simon R. Green, Susan H. Davis, Sebastian Damerow, Curtis A. Engelhart, Michael Mathieson, Beatriz Baragaña, David A. Robinson, Jevgenia Tamjar,..

Common and unique features of glycosylation and glycosyltransferases in African trypanosomes

Samuel M. Duncan, Michael A.J. Ferguson. Biochem J (2022) 479 (17): 1743–1758. Abstract Eukaryotic protein glycosylation is mediated by glycosyl- and..

Genome-scale RNA interference profiling of Trypanosoma brucei cell cycle progression defects.

Catarina A. Marques, Melanie Ridgway, Michele Tinti, Andrew Cassidy & David Horn Nat Commun 13, 5326 (2022). https://doi.org/10.1038/s41467-022-33109-y Abstract Trypanosomatids, which..

Drug discovery research in Ghana, challenges, current efforts, and the way forward

Richard Kwamla Amewu , Patrick Amoateng, Patrick Kobina Arthur, Prince Asare, Isaac Asiamah, Daniel Boamah, Isaac Darko Otchere, Cedric Dzidzor..

Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase

Rachel Milne, Natalie Wiedemar, Victoriano Corpas-Lopez, Eoin Moynihan, Richard J. Wall, Alice Dawson, David A. Robinson, Sharon M. Shepherd, Robert..

Anti-trypanosomatid drug discovery: progress and challenges.

Manu De Rycker, Susan Wyllie, David Horn, Kevin D Read, Ian H Gilbert. Nat Rev Microbiol. 2022 Aug 22:1–16. doi:..

Genetic Transformation of Candida auris via Homology-Directed Repair Using a Standard Lithium Acetate Protocol

Gustavo Bravo Ruiz & Alexander Lorenz Methods in Molecular Biology, vol 2517. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2417-3_8 Abstract Reverse..

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