Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium

Jack C. Hanna, Victor Corpas-Lopez, Simona Seizova, Beatrice L. Colon, Ross Bacchetti, Grant M. J. Hall, Emma M. Sands, Lee..

Ethanolaminephosphate cytidylyltransferase is essential for survival, lipid homeostasis and stress tolerance in Leishmania major

Somrita Basu, Mattie C. Pawlowic, Fong-Fu Hsu, Geoff Thomas, Kai Zhang. PLoS Pathog 19(7): e1011112. Abstract Glycerophospholipids including phosphatidylethanolamine (PE)..

Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors

Michael G Thomas , Kate McGonagle , Paul Rowland , David A Robinson , Peter G Dodd , Isabel Camino-Díaz..

Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in Trypanosoma brucei

Bachmaier, Sabine, Gould, Matthew K., Polatoglou, Eleni, Omelianczyk, Radoslaw, Brennand, Ana E., Aloraini, Maha A., Munday, Jane C., Horn, David,..

Competition among variants is predictable and contributes to the antigenic variation dynamics of African trypanosomes

Douglas O. Escrivani ,Viktor Scheidt ,Michele Tinti, Joana Faria, David Horn. PLOS Pathogens 19(7): e1011530. https://doi.org/10.1371/journal.ppat.1011530 Abstract Several persistent pathogens employ..

Bespoke Drug Discovery Training for Low-Middle Income Countries

Lauren A. Webster, Susan J. Farrell, Ian H. Gilbert, and Kevin D. Read ACS Med. Chem. Lett. 2023, XXXX, XXX, XXX-XXX Publication..

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues

Laura A. T. Cleghorn, Richard J. Wall, Sébastien Albrecht, Stuart A. MacGowan, Suzanne Norval, Manu De Rycker, Andrew Woodland, Daniel..

The critical role of mode of action studies in kinetoplastid drug discovery

Alan H. Fairlamb and Susan Wyllie Front. Drug Discov., 10 May 2023 Sec. Anti-Infective Agents, Volume 3 - 2023 Understanding..

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum

Krittikorn Kümpornsin, Theerarat Kochakarn, Tomas Yeo, John Okombo, Madeline R. Luth, Johanna Hoshizaki, Mukul Rawat, Richard D. Pearson, Kyra A...

Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline

Oriana Kreutzfeld , Patrick K Tumwebaze , Martin Okitwi , Stephen Orena , Oswald Byaruhanga , Thomas Katairo , Melissa..

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