Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy

Nicola Caldwell , Caroline Peet, Peter Miller, Beatrice L. Colon, Malcolm G. Taylor, Mattia Cocco, Alice Dawson , Iva Lukac,..

Post-transcriptional reprogramming by thousands of mRNA untranslated regions in trypanosomes

Anna Trenaman, Michele Tinti, Richard J. Wall & David Horn Nat Commun 15, 8113 (2024). Abstract Although genome-wide polycistronic transcription places..

ResMAP-a saturation mutagenesis platform enabling parallel profiling of target-specific resistance-conferring mutations in Plasmodium

Richard J Wall , Stuart A MacGowan , Irene Hallyburton , Aisha J Syed , Sowmya Ajay Castro , Gourav..

The major surface protein of malaria sporozoites is GPI-anchored to the plasma membrane

Rupa Nagar, Stefano S Garcia Castillo, Maria Pinzon-Ortiz, Sharon Patray, Alida Coppi, Sachie Kanatani, Robert L Moritz, Kristian E Swearingen,..

A proposed pathway from D-glucose to D-arabinose in eukaryotes

Elda Iljazi, Rupa Nagar, Sabine Kuettel, Kieron Lucas, Arthur Crossman, Marie-Ange Badet-Denisot, Ronald W. Woodard, Michael A.J. Ferguson. Journal of..

Superior Anticancer and Antifungal Activities of New Sulfanyl-Substituted Niclosamide Derivatives

Ma, Jingyi, Dileepkumar Veeragoni, Hindole Ghosh, Nicole Mutter, Gisele Barbosa [1], Lauren Webster, Rainer Schobert, Wendy van de Sande, Prasad..

Generation of a bloodstream form Trypanosoma brucei double glycosyltransferase null mutant competent in receptor-mediated endocytosis of transferrin

Samuel M. Duncan, Carla Gilabert Carbajo, Rupa Nagar, Qi Zhong, Conor Breen, Michael A. J. Ferguson ,Calvin Tiengwe PLOS Pathogens..

Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1

Lindsay B. Tulloch, Michele Tinti, Richard J. Wall, Stefan K. Weidt, Victoriano Corpas- Lopez, Gourav Dey, Terry K. Smith, Alan..

Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential

Omar Khoumeri, Sébastien Hutter, Nicolas Primas, Caroline Castera-Ducros, Sandra Carvalho, Susan Wyllie, Mohamed Lotfi Efrit, Dimitri Fayolle, Marc Since, Patrice..

Accurate prediction of dynamic protein–ligand binding using P-score ranking

Peter E. G. F. Ibrahim, Fabio Zuccotto, Ulrich Zachariae, Ian Gilbert, Mike Bodkin J. Comput. Chem. 2024, 45(20), 1762. Abstract Protein–ligand binding prediction typically relies on docking..

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