RES-Seq—a barcoded library of drug-resistant Leishmania donovani allowing rapid assessment of cross-resistance and relative fitness

Lindsay B. Tulloch, Sandra Carvalho, Marta Lima, Richard J. Wall, Michele Tinti, Erika G. Pinto, Lorna MacLean, Susan Wyllie. Antimicrobial..

Small-Molecule Antibiotic Drug Development: Need and Challenges

Megan Bergkessel, Barbara Forte, and Ian H. Gilbert. ACS Infect. Dis. 2023, 9, 11, 2062–2071 Publication Date:October 11, 2023 https://doi.org/10.1021/acsinfecdis.3c00189 Abstract The..

Characterisation of TcFUT1, a mitochondrial fucosyltransferase from Trypanosoma cruzi

Jose Carlos Paredes Franco, Maria Lucia Sampaio Guther, Marta L. Lima, Michael A.J. Ferguson Molecular and Biochemical Parasitology Vol 256,..

Characterization of the major surface glycoconjugates of Trypanosoma theileri

Rupa Nagar, Isobel Hambleton, Michele Tinti, Mark Carrington, Michael A.J. Ferguson Molecular and Biochemical Parasitology, Vol 256, 111591 Abstract Trypanosoma theileri maintains..

Identification of the glycosylphosphatidylinositol-specific phospholipase A2 (GPI-PLA2) that mediates GPI fatty acid remodeling in Trypanosoma brucei

Zhe Ji , Rupa Nagar, Samuel M. Duncan, Maria Lucia Sampaio Guther, Michael A.J. Ferguson. Journal of Biological Chemistry 299,..

Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium

Jack C. Hanna, Victor Corpas-Lopez, Simona Seizova, Beatrice L. Colon, Ross Bacchetti, Grant M. J. Hall, Emma M. Sands, Lee..

Ethanolaminephosphate cytidylyltransferase is essential for survival, lipid homeostasis and stress tolerance in Leishmania major

Somrita Basu, Mattie C. Pawlowic, Fong-Fu Hsu, Geoff Thomas, Kai Zhang. PLoS Pathog 19(7): e1011112. Abstract Glycerophospholipids including phosphatidylethanolamine (PE)..

Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors

Michael G Thomas , Kate McGonagle , Paul Rowland , David A Robinson , Peter G Dodd , Isabel Camino-Díaz..

Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in Trypanosoma brucei

Bachmaier, Sabine, Gould, Matthew K., Polatoglou, Eleni, Omelianczyk, Radoslaw, Brennand, Ana E., Aloraini, Maha A., Munday, Jane C., Horn, David,..

Competition among variants is predictable and contributes to the antigenic variation dynamics of African trypanosomes

Douglas O. Escrivani ,Viktor Scheidt ,Michele Tinti, Joana Faria, David Horn. PLOS Pathogens 19(7): e1011530. https://doi.org/10.1371/journal.ppat.1011530 Abstract Several persistent pathogens employ..

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