Phylogenomic reconstruction of Cryptosporidium spp. captured directly from clinical samples reveals extensive genetic diversity

A. Khan, E.V.C. Alves-Ferreira, H. Vogel, S. Botchie, S I. Ayi, M.C. Pawlowic, G. Robinson, R.M. Chalmers, H. Lorenzi, M.E. Grigg bioRxiv 2024.04.17.589752 doi: https://doi.org/10.1101/2024.04.17.589752 Abstract Cryptosporidium is a leading cause of severe diarrhea and mortality in young children and..

The bloodstream form of Trypanosoma brucei displays non-canonical gluconeogenesis

Kovářová, Julie; Moos, Martin; Barrett, Michael P.; Horn, David; Zíková, Alena. PLOS Neglected Tropical Diseases 18(2): e0012007 Abstract Trypanosoma brucei..

Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity

Izquierdo, Maikel; Lin, De; O’Neill, Sandra; Webster, Lauren A.; Paterson, Christy; Thomas, John; Aguado, Mirtha Elisa; Araújo, Enrique Colina; Alpízar-Pedraza,..

Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism

A. Kenneth MacLeod, Kevin-Sebastien Coquelin, Leticia Huertas, Frederick R.C. Simeons, Jennifer Riley, Patricia Casado, Laura Guijarro, Ruth Casanueva, Laura Frame,..

Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase

Stanley C. Xie, Yinuo Wang, Craig J. Morton, Riley D. Metcalfe, Con Dogovski, Charisse Flerida A. Pasaje, Elyse Dunn, Madeline..

Design of the Global Health chemical diversity library v2 for screening against infectious diseases

Wilson, Caroline; Gardner, J. Mark F.; Gray, David W.; Baragana, Beatriz; Wyatt, Paul G.; Cookson, Alex; Thompson, Stephen; Mendoza-Martinez, Cesar;..

Genome-wide screens connect HD82 loss-of-function to purine analog resistance in African trypanosomes

Anna Trenaman, Michele Tinti , Abdelmadjid Atrih, David Horn Antimicrobrial Chemostherapy mSphere 9:e00363-23. Abstract Nucleoside analogs have been used extensively as..

Short-course combination treatment for experimental chronic Chagas disease

Silvia González, Richard J. Wall, John Thomas, Stephanie Braillard, Gino Brunori, Isabel Camino Díaz, Juan Cantizani, Sandra Carvalho, Pablo Castañeda..

DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1

Stéphanie Braillard , Martine Keenan, Karen J. Breese, Jacob Heppell, Michael Abbott, Rafiqul Islam, David M. Shackleford, Kasiram Katneni, Elly..

An allele-selective inter-chromosomal protein bridge supports monogenic antigen expression in the African trypanosome

Joana R. C. Faria, Michele Tinti, Catarina A. Marques, Martin Zoltner, Harunori Yoshikawa, Mark C. Field & David Horn. Nature..

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