Different chemical scaffolds bind to L-phe site in Mycobacterium tuberculosis Phe-tRNA synthetase

Priyanka Gade , Changsoo Chang , Denise S. Pryde , Daniel Fletcher , Sarah Niven , Luma Godoy Magalhaes ,..

Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity

Mukul Rawat, Gilda Padalino, Edem Adika, John Okombo, Tomas Yeo, Andrea Brancale, David A. Fidock, Karl F. Hoffmann, Marcus C...

The Trypanosoma cruzi cell atlas; a single-cell resource for understanding parasite population heterogeneity and differentiation

Ross Laidlaw, Marta Garcia Sanchez, Juliana Da Silva Pacheco, Luciana De Sousa Paradela, Thomas D Otto, Manu De Rycker bioRxiv 2024.10.01.616042; doi: https://doi.org/10.1101/2024.10.01.616042..

Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors

Thomas C. Eadsforth , Leah S. Torrie, Paul Rowland*, Emma V. Edgar*, Lorna M. MacLean, Christy Paterson, David A. Robinson,..

Use of Crithidia fasciculata extract for the facile enzymatic synthesis of GDP-L-[3H]Fucose

Jose Carlos Paredes Franco , Maria Lucia Sampaio Güther , Michael A J Ferguson Glycobiology, Volume 35, Issue 2, February 2025, cwae097 Abstract For..

SPPIRIT: a network connecting Scottish early-career researchers in parasitology

Rebecca C.S. Edgar, Jack Hanna, Markéta Novotná, Marta Campillo Poveda, Mukul Rawat, Shikha Shikha, Frank Venter, Melanie C. Ridgway. Trends..

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance

Madeline R. Luth, Karla P. Godinez-Macias , Daisy Chen , John Okombo, Vandana Thathy , Xiu Cheng, Sindhu Daggupati ,..

A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants

Letícia Tiburcio Ferreira, Gustavo Capatti Cassiano, Luis Carlos Salazar Alvarez, John Okombo, Juliana Calit, Diana Fontinha, Eva Gil-Iturbe, Rachael Coyle,..

Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against Mycobacterium abscessus and Mycobacterium avium, Two Emerging Human Pathogens

Matheus Andrade Meirelles, Vitor M. Almeida, Jaryd R. Sullivan, Ian de Toledo, Caio Vinicius dos Reis, Micael Rodrigues Cunha, Rachel..

β-Carboline-3-carboxamide Antimalarials: Structure-Activity Relationship, ADME-Tox Studies, and Resistance Profiling

Jopaul Mathew,Bo Zhou; Reagan S. Haney, Kevin A. Kunz, Leticia S. Do Amaral, Rudraneel Roy Chowdhury, Joshua H. Butler, Haibo..

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