Drug resistance–associated mutations in Plasmodium UBP-1 disrupt its essential deubiquitinating activity

Cameron J. Smith Heledd Eavis, Carla Briggs, Ryan Henrici , Maryia Karpiyevich , Megan R. Ansbro , Johanna Hoshizaki ,..

Identification of a series containing a pentafluorophenyl moiety that targets Pks13 to inhibit growth of Mycobacterium tuberculosis

Simon Green , Justin Harrison, Stephen Thompson, Dinakaran Murugesan, M. Daben J. Libardo, Curtis A. Engelhart, Jaclynn Meshanni, Daniel A...

Use of an extensively humanized mouse model to predict the risk of drug–drug interactions in patients receiving dexamethasone

Jacob George, James D. Chalmers, Kevin-Sebastien Coquelin, Laura Frame, Colin J. Henderson, Yury Kapelyukh, Chim C. Lang, Kevin D. Read,..

Different chemical scaffolds bind to L-phe site in Mycobacterium tuberculosis Phe-tRNA synthetase

Priyanka Gade , Changsoo Chang , Denise S. Pryde , Daniel Fletcher , Sarah Niven , Luma Godoy Magalhaes ,..

Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity

Mukul Rawat, Gilda Padalino, Edem Adika, John Okombo, Tomas Yeo, Andrea Brancale, David A. Fidock, Karl F. Hoffmann, Marcus C...

The Trypanosoma cruzi cell atlas; a single-cell resource for understanding parasite population heterogeneity and differentiation

Ross Laidlaw, Marta Garcia Sanchez, Juliana Da Silva Pacheco, Luciana De Sousa Paradela, Thomas D Otto, Manu De Rycker bioRxiv 2024.10.01.616042; doi: https://doi.org/10.1101/2024.10.01.616042..

Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors

Thomas C. Eadsforth , Leah S. Torrie, Paul Rowland*, Emma V. Edgar*, Lorna M. MacLean, Christy Paterson, David A. Robinson,..

Use of Crithidia fasciculata extract for the facile enzymatic synthesis of GDP-L-[3H]Fucose

Jose Carlos Paredes Franco , Maria Lucia Sampaio Güther , Michael A J Ferguson Glycobiology, Volume 35, Issue 2, February 2025, cwae097 Abstract For..

SPPIRIT: a network connecting Scottish early-career researchers in parasitology

Rebecca C.S. Edgar, Jack Hanna, Markéta Novotná, Marta Campillo Poveda, Mukul Rawat, Shikha Shikha, Frank Venter, Melanie C. Ridgway. Trends..

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance

Madeline R. Luth, Karla P. Godinez-Macias , Daisy Chen , John Okombo, Vandana Thathy , Xiu Cheng, Sindhu Daggupati ,..

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