Decoding post-transcriptional gene expression controls in trypanosomatids using machine learning

Michele Tinti, David Horn [version 2; peer review: 3 approved]. Wellcome Open Res 2025, 10:173 (https://doi.org/10.12688/wellcomeopenres.23817.2) Plain Language Summary We study how three..

Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes

Markéta Novotná , Michele Tinti , Joana R C Faria , David Horn Nature Communications. 2025 Jul 4;16(1):6194. doi: 10.1038/s41467-025-61480-z..

Structure–activity relationships of 1,5-dihydro-2H-benzo[b][1,4]diazepine-2,4(3H)-diones as inhibitors of Trypanosoma cruzi

Michael G Thomas, Joanne Dunne, Peter G Dodd, Emiliana D'Oria, Laura Frame, Adolfo Garcia-Perez, Kate McGonagle, Pilar Manzano, Lorna MacLean,..

Inner-mitochondrial membrane protein PfMPV17 is linked to P. falciparum in vitro resistance to the indoloquinolizidine alkaloid alstonine

J. R. Macdonald, M. S. Arnold, M. R. Luth, D. Cihalova, R. J. Quinn, E. A. Winzeler, M. C. Lee, G...

The Thienopyrimidinone Gamhépathiopine Targets the QO Site of Plasmodium falciparum Cytochrome b

Natalie Wiedemar, Rachel Milne, Sandra Carvalho, Stephen Patterson, Mike Bodkin, Nicolas Masurier, Vincent Lisowski, Nicolas Primas, Pierre Verhaegh, Graeme M...

Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4

Jon Kyle Awalt, Zi Kang Ooi, Trent D. Ashton, Mahta Mansouri, Petar P. S. Calic, Qingmiao Zhou, Santhya Vasanthan, Serena..

Navigating the Landscape of Academic Drug Discovery: An 18-Year Journey

Beatriz Baragaña and Laura A. T. Cleghorn J. Med. Chem. 2025, 68, 8, 7847–7851 A reflection on the 18..

Drug resistance–associated mutations in Plasmodium UBP-1 disrupt its essential deubiquitinating activity

Cameron J. Smith Heledd Eavis, Carla Briggs, Ryan Henrici , Maryia Karpiyevich , Megan R. Ansbro , Johanna Hoshizaki ,..

Identification of a series containing a pentafluorophenyl moiety that targets Pks13 to inhibit growth of Mycobacterium tuberculosis

Simon Green , Justin Harrison, Stephen Thompson, Dinakaran Murugesan, M. Daben J. Libardo, Curtis A. Engelhart, Jaclynn Meshanni, Daniel A...

Use of an extensively humanized mouse model to predict the risk of drug–drug interactions in patients receiving dexamethasone

Jacob George, James D. Chalmers, Kevin-Sebastien Coquelin, Laura Frame, Colin J. Henderson, Yury Kapelyukh, Chim C. Lang, Kevin D. Read,..

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