Overcoming a false-positive mechanism in RapidFire MRM-based high throughput screening

De Lin, Lesley-Anne Pearson, Shamshad Ahmad, Sandra O'Neill, John Post, Colin Robinson, Duncan E Scott, Ian H Gilbert. SLAS Discovery..

Comparative metabolism of conjugated and unconjugated pterins in Crithidia, Leishmania and African trypanosomes.

Han B. Ong, Susan Wyllie, Alan H. Fairlamb Neglected Tropical Diseases 19(7): e0013332 Abstract Mammalian cells synthesise tetrahydrobiopterin de novo,..

Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1

William Nguyen, Coralie Boulet, Madeline G. Dans, Katie Loi, Kate E. Jarman, Claudia B. G. Barnes, Tomas Yeo, Tanaya Sheth,..

Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity

Nardella, Florea; Jiang, Tiantianb; Wang, Lushunc;Bohmer, Monica J.a; Chakraborty, Subhojaa; ...Marcus C.S. Lee...Debopma Chakrabati. Cell Chemical Biology Volume 32, Issue..

Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.

Lindsay B. Tulloch, Hugh Tawell, Annie E. Taylor, Marta Lopes Lima , Alice Dawson , Sandra Carvalho, Richard J. Wall,..

Identification of potent inhibitors ofLeishmania donovani and Leishmania infantum chagasi, the causative agents of Old and New World visceral leishmaniasis

Bilal Zulfiqar , Fabio Antonio Colombo , Juliana Barbosa Nunes , Patricia Ferreira Espuri , Aurea Favero Ferreira, Sujatha Manthri..

Decoding post-transcriptional gene expression controls in trypanosomatids using machine learning

Michele Tinti, David Horn [version 2; peer review: 3 approved]. Wellcome Open Res 2025, 10:173 (https://doi.org/10.12688/wellcomeopenres.23817.2) Plain Language Summary We study how three..

Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes

Markéta Novotná , Michele Tinti , Joana R C Faria , David Horn Nature Communications. 2025 Jul 4;16(1):6194. doi: 10.1038/s41467-025-61480-z..

Structure–activity relationships of 1,5-dihydro-2H-benzo[b][1,4]diazepine-2,4(3H)-diones as inhibitors of Trypanosoma cruzi

Michael G Thomas, Joanne Dunne, Peter G Dodd, Emiliana D'Oria, Laura Frame, Adolfo Garcia-Perez, Kate McGonagle, Pilar Manzano, Lorna MacLean,..

Inner-mitochondrial membrane protein PfMPV17 is linked to P. falciparum in vitro resistance to the indoloquinolizidine alkaloid alstonine

J. R. Macdonald, M. S. Arnold, M. R. Luth, D. Cihalova, R. J. Quinn, E. A. Winzeler, M. C. Lee, G...

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