Challenges and recent progress in drug discovery for tropical diseases.

De Rycker M, Baragaña B, Duce SL, Gilbert IH. Nature 559, 498–506 (2018) Infectious tropical diseases have a huge effect in terms of..

Comparative proteomics of the two T. brucei PABPs suggests that PABP2 controls bulk mRNA.

Zoltner M, Krienitz N, Field MC, Kramer S. PLoS Negl Trop Dis. 2018;12(7). Poly(A)-binding proteins (PABPs) regulate mRNA fate by..

The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei.

Kelner A, Tinti M, Guther MLS, Foth BJ, Chappell L, Berriman M, et al. PLoS One [Internet]. 2018;13(7):e0201263. Messenger RNA..

Adaptation and Therapeutic Exploitation of the Plasma Membrane of African Trypanosomes.

Quintana JF, Canavate R, Pino D, Yamada K, Zhang N, Field MC. Genes 2018, 9, 368. African trypanosomes are highly..

Faster growth with shorter antigens can explain a VSG hierarchy during African trypanosome infections: a feint attack by parasites.

Liu D, Albergante L, Newman TJ, Horn D. Sci Rep [Internet]. 2018;8(1). The parasitic African trypanosome, Trypanosoma brucei, evades the..

Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas’ disease drug discovery.

MacLean LM, Thomas J, Lewis MD, Cotillo I, Gray DW, De Rycker M. PLoS Negl Trop Dis [Internet]. 2018;12(7):e0006612. Chagas’..

Melarsoprol Resistance in African Trypanosomiasis

Fairlamb Alan H, Horn David Trends Parasitology Volume 34, Issue 6, June 2018, Pages 481-492 Arsenical monotherapies were previously very..

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

Cleghorn LAT, Ray PC, Odingo J, Kumar A, Wescott H, Korkegian A, et al. J Med Chem. 2018;61(15):6592–608. With the..

Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis

Fairlamb, Alan H and Patterson S. Current Medicinal Chemistry 25, 1–20, 2018 Interest in nitroheterocyclic drugs for the treatment of..

Evolutionary origins and specialisation of membrane transport.

Dacks Joel B, Field Mark C. Curr Opin Cell Biol. 2018;53:70–6. From unicellular protists to the largest megafauna and flora, all eukaryotes depend upon..

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