Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial

Luciana S. Paradela, Richard J. Wall, Sandra Carvalho, Giulia Chemi, Victoriano Corpas-Lopez, Eoin Moynihan, Davide Bello, Stephen Patterson, Maria Lucia..

Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Michael Thomas, Stephen Brand, Manu De Rycker, Fabio Zuccotto, Iva Lukac, Peter G. Dodd, Eun-Jung Ko, Sujatha Manthri, Kate McGonagle,..

Proteomic identification of the UDP-GlcNAc: PI α1–6 GlcNAc-transferase subunits of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei

Z Ji, M Tinti, MAJ Ferguson PLos One Volume 16, Issue 3 March, March 2021, Article number e0244699 doi 10.1371/journal.pone.0244699..

Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis

M. Daben J.Libardo, Caroline J.Duncombe, Simon R.Green, Paul G.Wyatt, Stephen Thompson, Peter C. Ray, Thomas R. Ioerger, Sangmi Oh, Michael..

Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities.

Lauren B Arendse, Susan Wyllie, Kelly Chibale, Ian H Gilbert. ACS Infect Dis. 2021 Mar 12;7(3):518-534. doi: 10.1021/acsinfecdis.0c00724. Epub 2021..

Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry

Lesley-Anne Pearson, Charlotte J Green, De Lin, Alain-Pierre Petit, David W Gray, Victoria H Cowling, Euan A F Fordyce. SLAS..

De Novo Synthesis of Phosphatidylcholine Is Essential for the Promastigote But Not Amastigote Stage in Leishmania major

Samrat Moitra, Somrita Basu, Mattie Pawlowic, Fong-fu Hsu and Kai Zhang Front. Cell. Infect. Microbiol., 12 March 2021 | https://doi.org/10.3389/fcimb.2021.647870..

MalDA, Accelerating Malaria

Tuo Yang, Sabine Ottilie, Eva S Istvan, Karla P Godinez-Macias, Amanda K Lukens, Beatriz Baragaña, Brice Campo, Chris Walpole, Jacquin..

A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research

Suzannah J. Rihn , Andres Merits , Siddharth Bakshi , Matthew L. Turnbull , Arthur Wickenhagen , Akira J. T...

Structure-Activity Relationships of Pyrazolo[1,5- a]pyrimidin-7(4 H)-ones as Antitubercular Agents

Sangmi Oh, M Daben J Libardo, Shaik Azeeza, Gary T Pauly, Jose Santinni O Roma, Andaleeb Sajid, Yoshitaka Tateishi, Caroline..

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