Melarsoprol Resistance in African Trypanosomiasis

Fairlamb Alan H, Horn David Trends Parasitology Volume 34, Issue 6, June 2018, Pages 481-492 Arsenical monotherapies were previously very..

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

Cleghorn LAT, Ray PC, Odingo J, Kumar A, Wescott H, Korkegian A, et al. J Med Chem. 2018;61(15):6592–608. With the..

Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis

Fairlamb, Alan H and Patterson S. Current Medicinal Chemistry 25, 1–20, 2018 Interest in nitroheterocyclic drugs for the treatment of..

Evolutionary origins and specialisation of membrane transport.

Dacks Joel B, Field Mark C. Curr Opin Cell Biol. 2018;53:70–6. From unicellular protists to the largest megafauna and flora, all eukaryotes depend upon..

Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes.

Rico E, Jeacock L, Kovářová J, Horn D. Scientific Reports. 2018;8(1):7960. The Cas9 endonuclease can be programmed by guide RNA..

Characterisation of a putative glutamate 5-kinase from Leishmania donovani.

Sienkiewicz N, Ong HB, Fairlamb AH. FEBS J. 2018;285(14):2662–78. Previous metabolic studies have demonstrated that leishmania parasites are able to..

Generation of Polar Semi-Saturated Bicyclic Pyrazoles for Fragment-Based Drug-Discovery Campaigns.

Luise N, Wyatt PG Chem - A Eur J. 2018;24(41):10443–51 Synthesising polar semi‐saturated bicyclic heterocycles can lead to better starting..

Proteomic analysis of the cell cycle of procylic form Trypanosoma brucei.

Crozier TWM, Tinti M, Wheeler RJ, Ly T, Ferguson MAJ, Lamond AI. Mol Cell Proteomics [Internet]. 2018 Mar 19; We..

Codon usage bias controls mRNA and protein abundance in trypanosomatids.

Jeacock L, Faria J, Horn D. elife. 2018;7:e32496. Protein abundance differs from a few to millions of copies per cell. Trypanosoma..

2-Mercapto-quinazolinones as inhibitors of NDH-2 and Mycobacterium tuberculosis: Structure-activity relationships, mechanism of action and ADME characterization.

Murugesan D, Ray PC, Bayliss T, Prosser GA, Harrison JR, Green K, et al. ACS Infect. Dis. 2018, 4, 6,..

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