Visualisation of proteome-wide ordered protein abundances in Trypanosoma brucei

Michele Tinti , Michael A J Ferguson Wellcome Open Res . 2022 Jan 31;7:34. doi: 10.12688/wellcomeopenres.17607.1. eCollection 2022. Abstract Background:..

Visualisation of experimentally determined and predicted protein N-glycosylation and predicted glycosylphosphatidylinositol anchor addition in Trypanosoma brucei

Tinti M., Ferguson M.A.J. Wellcome Open Res . 2022 Jan 31;7:33. doi: 10.12688/wellcomeopenres.17640.1. eCollection 2022. Abstract Background: Trypanosoma brucei is a protozoan parasite and..

Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target

Caroline Wilson, Peter Ray, Fabio Zuccotto, Jorge Hernandez, Anup Aggarwal, Claire Mackenzie, Nicola Caldwell, Malcolm Taylor, Margaret Huggett, Michael Mathieson,..

A profile of research on the parasitic trypanosomatids and the diseases they cause

David Horn PLOS Neglected Tropical Diseases 16(1): e0010040. https://doi.org/10.1371/journal.pntd.0010040 Abstract The parasitic trypanosomatids cause lethal and debilitating diseases, the leishmaniases,..

Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas’ Disease

Marta L. Lima, Lindsay B. Tulloch, Victoriano Corpas-Lopez, Sandra Carvalho, Richard J. Wall, Rachel Milne, Eva Rico, , Stephen Patterson,..

Evaluation of antileishmanial potential of the antidepressant escitalopram in Leishmania infantum

Marta Lopes Lima, Maiara Amaral, Samanta Etel Treiger Borborem, Andre Gustavo Tempone Journal of Pharmaceutical and Biomedical Analysis Volume 209,..

The role of DMPK science in improving pharmaceutical research and development efficiency

Kit-Kay Mak*, Ola Epemolu , Mallikarjuna Rao Pichika Drug Discovery Today, https://doi.org/10.1016/j.drudis.2021.11.005 Abstract The successful regulatory authority approval rate of..

DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Charles E. Mowbray*, Stéphanie Braillard, Paul A. Glossop, Gavin A. Whitlock, Robert T. Jacobs, Jason Speake, Bharathi Pandi, Bakela Nare,..

Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay

Nina Svensen, Susan Wyllie, David W. Gray, Manu De Rycker PLOS Neglected Tropical Diseases 15(10): e0009870. https://doi.org/10.1371/journal.pntd.0009870 Abstract Chagas disease, caused..

Genome-scale RNAi screens in African trypanosomes

David Horn Trends in Parasitology 2021. Sep 24;S1471-4922(21)00226-9. doi: 10.1016/j.pt.2021.09.002 Genome-scale genetic screens allow researchers to rapidly identify the genes and..

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