Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.

Lindsay B. Tulloch, Hugh Tawell, Annie E. Taylor, Marta Lopes Lima , Alice Dawson , Sandra Carvalho, Richard J. Wall,..

The Thienopyrimidinone Gamhépathiopine Targets the QO Site of Plasmodium falciparum Cytochrome b

Natalie Wiedemar, Rachel Milne, Sandra Carvalho, Stephen Patterson, Mike Bodkin, Nicolas Masurier, Vincent Lisowski, Nicolas Primas, Pierre Verhaegh, Graeme M...

Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4

Jon Kyle Awalt, Zi Kang Ooi, Trent D. Ashton, Mahta Mansouri, Petar P. S. Calic, Qingmiao Zhou, Santhya Vasanthan, Serena..

Navigating the Landscape of Academic Drug Discovery: An 18-Year Journey

Beatriz Baragaña and Laura A. T. Cleghorn J. Med. Chem. 2025, 68, 8, 7847–7851 A reflection on the 18..

Drug resistance–associated mutations in Plasmodium UBP-1 disrupt its essential deubiquitinating activity

Cameron J. Smith Heledd Eavis, Carla Briggs, Ryan Henrici , Maryia Karpiyevich , Megan R. Ansbro , Johanna Hoshizaki ,..

Use of an extensively humanized mouse model to predict the risk of drug–drug interactions in patients receiving dexamethasone

Jacob George, James D. Chalmers, Kevin-Sebastien Coquelin, Laura Frame, Colin J. Henderson, Yury Kapelyukh, Chim C. Lang, Kevin D. Read,..

Different chemical scaffolds bind to L-phe site in Mycobacterium tuberculosis Phe-tRNA synthetase

Priyanka Gade , Changsoo Chang , Denise S. Pryde , Daniel Fletcher , Sarah Niven , Luma Godoy Magalhaes ,..

Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity

Mukul Rawat, Gilda Padalino, Edem Adika, John Okombo, Tomas Yeo, Andrea Brancale, David A. Fidock, Karl F. Hoffmann, Marcus C...

The Trypanosoma cruzi cell atlas; a single-cell resource for understanding parasite population heterogeneity and differentiation

Ross Laidlaw, Marta Garcia Sanchez, Juliana Da Silva Pacheco, Luciana De Sousa Paradela, Thomas D Otto, Manu De Rycker bioRxiv 2024.10.01.616042; doi: https://doi.org/10.1101/2024.10.01.616042..

Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors

Thomas C. Eadsforth , Leah S. Torrie, Paul Rowland*, Emma V. Edgar*, Lorna M. MacLean, Christy Paterson, David A. Robinson,..

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