Biophysical analysis of an oligomerization-attenuated variant of the Leishmania donovani dynamin-1-like protein

Ellen Wuyts , Ramasubramanian Sundaramoorthy , Lindsay Tulloch , Pieter Monsieurs , Thomas C Eadsforth , Isabel Pintelon , Jean-Pierre..

Decoding efficacy and resistance space at a drug binding site

Simone Altmann, Cesar Mendoza-Martinez, Melanie Ridgway, Michele Tinti, Jagmohan S. Saini, Peter E. G. F. Ibrahim, Michael Thomas, Manu De Rycker, Michael J. Bodkin, David Horn bioRxiv 2025.07.25.666894; doi: https://doi.org/10.1101/2025.07.25.666894 This article is a preprint and has not been certified by peer..

Comparative metabolism of conjugated and unconjugated pterins in Crithidia, Leishmania and African trypanosomes.

Han B. Ong, Susan Wyllie, Alan H. Fairlamb Neglected Tropical Diseases 19(7): e0013332 Abstract Mammalian cells synthesise tetrahydrobiopterin de novo,..

Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity

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Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes

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Structure–activity relationships of 1,5-dihydro-2H-benzo[b][1,4]diazepine-2,4(3H)-diones as inhibitors of Trypanosoma cruzi

Michael G Thomas, Joanne Dunne, Peter G Dodd, Emiliana D'Oria, Laura Frame, Adolfo Garcia-Perez, Kate McGonagle, Pilar Manzano, Lorna MacLean,..

The Thienopyrimidinone Gamhépathiopine Targets the QO Site of Plasmodium falciparum Cytochrome b

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Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4

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Navigating the Landscape of Academic Drug Discovery: An 18-Year Journey

Beatriz Baragaña and Laura A. T. Cleghorn J. Med. Chem. 2025, 68, 8, 7847–7851 A reflection on the 18..

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