A non-coding role for trypanosome VSG transcripts in allelic exclusion

Douglas O Escrivani, Sebastian Hutchinson, Michele Tinti, Jane E Wright, Catarina A Marques, Joana R C Faria, Anna Trenaman, David Horn Nucleic Acids Research, Volume 53, Issue 19,..

Application of a mouse model humanized for cytochrome P450–mediated drug metabolism to predict drug-drug interactions between a peptide and small molecule drugs

Yury Kapelyukh, Charlotte Gabel-Jensen, Alastaire Kenneth MacLeod, Kevin-Sebastien Daniel Coquelin, Laste Stojanovski, Laura Frame, Amy Tavendale, Colin J. Henderson, Kevin..

Discovery of a CNS active GSK3 degrader using orthogonally reactive linker screening

Andreas Holmqvist, Nur Mehpare Kocaturk, Christina Duncan, Jennifer Riley, Steven Baginski, Graham Marsh, Joel Cresser-Brown, Hannah Maple, Kristiina Juvonen, Gajanan..

Protocol for a human placental explant model to study acute responses to pathogens

Elias R. Ruiz-Morales, Regina Hoo, Ross F. Waller, Marcus C.S. Lee, David Fernandez-Antoran , Iva Kelava , Roser Vento-Tormo STAR..

Investigation of Ximenia afra Sond. var. afra L. as a source of antiplasmodial and trypanocidal phytochemicals through accelerated bioactivity guided isolation

Wiehana Rudolph, Lauren Webster, Cedric Graebin, Vinesh Maharaj South African Journal of Botany Article 2025 Abstract Ethnopharmacological relevance: Ximenia afra..

Common Biological Properties of Mycobacterium tuberculosis MmpL3 Inhibitors

Lauren Ames, Renee Allen, Helena I. M. Boshoff, Laura A. T. Cleghorn, Curtis A. Engelhart, Dirk Schnappinger, Tanya Parish* ACS..

Biophysical analysis of an oligomerization-attenuated variant of the Leishmania donovani dynamin-1-like protein

Ellen Wuyts , Ramasubramanian Sundaramoorthy , Lindsay Tulloch , Pieter Monsieurs , Thomas C Eadsforth , Isabel Pintelon , Jean-Pierre..

Decoding efficacy and resistance space at a drug binding site

Simone Altmann, Cesar Mendoza-Martinez, Melanie Ridgway, Michele Tinti, Jagmohan S. Saini, Peter E. G. F. Ibrahim, Michael Thomas, Manu De Rycker, Michael J. Bodkin, David Horn bioRxiv 2025.07.25.666894; doi: https://doi.org/10.1101/2025.07.25.666894 This article is a preprint and has not been certified by peer..

Overcoming a false-positive mechanism in RapidFire MRM-based high throughput screening

De Lin, Lesley-Anne Pearson, Shamshad Ahmad, Sandra O'Neill, John Post, Colin Robinson, Duncan E Scott, Ian H Gilbert. SLAS Discovery..

Comparative metabolism of conjugated and unconjugated pterins in Crithidia, Leishmania and African trypanosomes.

Han B. Ong, Susan Wyllie, Alan H. Fairlamb Neglected Tropical Diseases 19(7): e0013332 Abstract Mammalian cells synthesise tetrahydrobiopterin de novo,..

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