The Basics of DMPK

This series will cover the theoretical background of drug metabolism and pharmacokinetics.  Why is it so important to drug discovery and how do we test these factors?

Absorption

How does a drug make it into your systemic circulation? What barriers does the drug have to face? This animated video explores the drugs journey from oral administration to entry into the liver, focussing on the ability of the drug to be absorbed.

Metabolism

What happens after a drug has been absorbed through the intestinal wall? The liver is responsible for the metabolism of xenobiotics and your drug. But how does the liver do this? Through this short animation, you will follow the journey of the drug as it attempts to continue on its journey to the systemic circulation.

Introduction to Drug Metabolism

This talk shows why an understanding  of drug metabolism is paramount to the fate of any compound. Drug metabolism can be responsible for the rapid metabolism of a compound and therefore it’s shorter duration of action.

Enzymes Involved in Metabolism

It is important to know that there are key enzymes responsible for  the metabolism of various compounds such as CYP450 and UGT. This will be discussed in this talk.

Introduction to Pharmacokinetics

This is the first of two talks that introduce the concepts of pharmacokinetics.  They describe what the body does to the drug as a function of time.  They will introduce the concepts of ADME/T.

Introduction to Pharmacokinetics Part 2

In this second and final talk, we continue to introduce the concepts of pharmacokinetics.  They describe what the body does to the drug as a function of time.  They will introduce the concepts of ADME/T.