Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes.

Rico E, Jeacock L, Kovářová J, Horn D. Scientific Reports. 2018;8(1):7960. The Cas9 endonuclease can be programmed by guide RNA..

Characterisation of a putative glutamate 5-kinase from Leishmania donovani.

Sienkiewicz N, Ong HB, Fairlamb AH. FEBS J. 2018;285(14):2662–78. Previous metabolic studies have demonstrated that leishmania parasites are able to..

Generation of Polar Semi-Saturated Bicyclic Pyrazoles for Fragment-Based Drug-Discovery Campaigns.

Luise N, Wyatt PG Chem - A Eur J. 2018;24(41):10443–51 Synthesising polar semi‐saturated bicyclic heterocycles can lead to better starting..

Proteomic analysis of the cell cycle of procylic form Trypanosoma brucei.

Crozier TWM, Tinti M, Wheeler RJ, Ly T, Ferguson MAJ, Lamond AI. Mol Cell Proteomics [Internet]. 2018 Mar 19; We..

Codon usage bias controls mRNA and protein abundance in trypanosomatids.

Jeacock L, Faria J, Horn D. elife. 2018;7:e32496. Protein abundance differs from a few to millions of copies per cell. Trypanosoma..

2-Mercapto-quinazolinones as inhibitors of NDH-2 and Mycobacterium tuberculosis: Structure-activity relationships, mechanism of action and ADME characterization.

Murugesan D, Ray PC, Bayliss T, Prosser GA, Harrison JR, Green K, et al. ACS Infect. Dis. 2018, 4, 6,..

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.

Zhang N, Zoltner M, Leung K-F, Scullion P, Hutchinson S, del Pino RC, et al. PLOS Pathog. 2018 Feb 9;14(2):e1006850..

Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.

Prati F, Zuccotto F, Fletcher D, Convery MA, Fernandez-Menendez R, Bates R, et al. ChemMedChem. 2018;13(7):672–7. Our findings reported herein..

Screening a protein kinase inhibitor library against Plasmodium falciparum.

Hallyburton I, Grimaldi R, Woodland A, Baragaña B, Luksch T, Spinks D, et al. Malar J [Internet]. 2017;16(1):446. Protein kinases..

Regulation of early endosomes across eukaryotes: Evolution and functional homology of Vps9 proteins.

Herman EK, Ali M, Field MC, Dacks JB. Traffic. 2018;19(7):546–63. Endocytosis is a crucial process in eukaryotic cells. The GTPases..

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