Development of a High-Throughput Screening Assay to Identify Inhibitors of the Major M17-Leucyl Aminopeptidase from Trypanosoma cruzi Using RapidFire Mass Spectrometry

Maikel Izquierdo*, De Lin, Sandra O'Neill, Martin Zoltner, Lauren Webster, Anthony Hope, David W. Gray, Mark C. Field, Jorge González-Bacerio*..

Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes

Martin Zoltner, Gustavo D Campagnaro, Gergana Taleva, Alana Burrell, Michela Cerone, Ka-Fai Leung, Fiona Achcar, David Horn, Sue Vaughan, Catarina..

Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase

Leah S. Torrie, David A. Robinson, Michael Thomas, Judith V Hobrath, Sharon M Shepherd, John M. Post, Eun-Jung Ko, Rafael..

Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease

Justin R. Harrison, Sandipan Sarkar, Shahienaz Hampton, Jennifer Riley, Laste Stojanovski, Christer Sahlberg, Pia Appelqvist, Jessey Erath, Vinodhini Mathan, Ana..

A One Health Approach to Tackle Cryptosporidiosis

Elisabeth A.Innes, Rachel M.Chalmers, BethWells, Mattie C.Pawlowic . Trends in Parasitology 2020 vol: 36 (3) pp: 290-303 DOI: 10.1016/J.PT.2019.12.016 Review Highlights Development of..

PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis

Qinglan Wang, Helena I. M. Boshoff, Justin R. Harrison, Peter C. Ray, Simon R. Green, Paul G. Wyatt, Clifton E. Barry III. Science ..

New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi

Julien Pedron, Clotilde Boudot, Jean-Yves Brossas, Emilie Pinault, Sandra Bourgeade-Delmas, Alix Sournia-Saquet, Elisa Boutet-Robinet, Alexandre Destere, Antoine Tronnet, Justine Bergé,..

The Qi site of cytochrome b is a promiscuous drug target in Trypanosoma cruzi and Leishmania donovani

Richard J Wall, Sandra Carvalho, Rachel Milne, Juan A. Bueren-Calabuig, Sonia Moniz, Juan Cantizani-Perez, Lorna MacLean, Albane Kessler, Ignacio Cotillo,..

Setting Our Sights on Infectious Diseases

De Rycker, Manu, Horn, David, Aldridge, Bree, Amewu, Richard K, Barry, Clifton E, Buckner, Frederick S, Cook, Sarah, Ferguson, Michael..

Genetic Manipulation of Cryptosporidium parvum with CRISPR/Cas9

Sateriale A, Pawlowic M, Vinayak S, Brooks C, Striepen B In: Mead JR, Arrowood MJ, editors. Cryptosporidium: Methods and Protocols..

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