Postdoctoral Position in Biotransformation

Ref: SLSC0703

Grade 7 (£32,817 – £40,322)

Closing Date: 4 March 2020

The Synthetic Methodologies team was established in the DDU through WCAIR funding in 2018. A key aim of the team is to establish high-throughput methods for synthesising compounds as part of hit to lead and lead optimisation programmes across all the DDU portfolios.

The team wish to recruit an exceptional individual to join us as a Postdoctoral Scientist in Biotransformation.

This position is to develop and establish in-house expertise in biotransformation in the following areas

  • Modification of late stage leads to modulate activity, safety and DMPK parameters.
  • Introduction of reaction handles for rapid hit and lead diversification.
  • Resolution of synthetic intermediates and final compounds particularly at scale.
  • Generation of potential metabolites to support DMPK Metabolism ID studies

The role will require the successful candidates to use their thorough knowledge of traditional and up to date biotransformation methodology. The successful candidate will have knowledge of practical organic chemistry and analysis and an ability to apply pragmatic solutions to rapidly move the project forward. In addition, you will work with colleagues in analytical chemistry, DMPK, informatics, computational chemistry and medicinal chemistry to ensure that the methods chosen are fit for purpose within the wider organisation.

The role requires you to be self-starting, to enjoy creative problem solving and work in new ways where required in order to deliver the project goals.
You will have the opportunity to help advance an internal culture of scientific excellence by identifying and championing emerging trends in the field, establishing yourself as an expert in biotransformation within the department and opportunities to mentor and support scientists within the DDU.

This posts is for one year initially and available immediately.

Skills and Knowledge


  • Ph.D. in an appropriate scientific discipline with experience in biotransformation and analysis.
  • Strong background in metabolite identification with hands on experience of LC/MS.
  • Demonstrable knowledge of up to date biotransformation/metabolism methods.
  • Practical experience of contemporary synthetic chemistry.
  •  Strong interpersonal, communication, organisational, time management and presentation skills.
  • Experience of the use of lab automation.
  • General IT skills.

For further information about this position please email Gary Tarver,

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