Job reference: SLSC0779
Salary: Grade 7 (£32,817-£40,322)
Closing date: Sunday 4 October
The Mode of Action group (MoA) are seeking to appoint a highly motivated postdoctoral researcher with appropriate skills in molecular and cell biology.
The MoA group, led by Dr Susan Wyllie, is focused on determining the mechanism of action and molecular targets of compounds that are phenotypically-active. To date this work has focused on kinetoplastid and Plasmodium parasites. We have developed an integrated drug target deconvolution strategy, employing an array of established and new methodologies encompassing high-throughput genetics, cell biology and chemical proteomics. We work closely with partners in academia and industry, and information emanating from our studies has been vital in guiding numerous drug discovery programmes.
We have recently received funding to broaden our scope to include drug target identification in Cryptosporidium. You will be dually appointed as a member of the MoA group, and a member of the Pawlowic lab, led by Dr Mattie Pawlowic. The Pawlowic lab create genetic and biochemical tools to investigate parasite transmission. They also collaborate with the MoA group and the Drug Discovery Unit to apply genetic tools to drug discovery.
You will benefit from being a member of both the Mode of Action and Pawlowic labs, and be at the forefront of developing molecular and cell biology tools to support drug target deconvolution for Cryptosporidium parasites. You will adopt existing methodologies currently used for target deconvolution in other parasites for use in Cryptosporidium, and you will have the opportunity to create new strategies and technologies for mode of action studies. You will gain skills in genetic manipulation of Cryptosporidium and use these skills to inform drug discovery. You will engage with project partners and contribute to exciting work to advance the development of therapeutics for cryptosporidiosis. As part of WCAIR you will interact with people working on a whole range of scientific disciplines and advanced technologies including mass spectrometry, cell and biochemical assay development, high-throughput screening, medicinal chemistry, in vivo models, and Drug Metabolism & Pharmacokinetics.
Highly desirable skills
This position is fixed-term, with funding available from 01 January 2021 until 31 December 2023.
Appointment on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. The initial appointment would be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 25 – 28 £29,176 – £31,866).
For more information please contact Susan Wyllie (firstname.lastname@example.org) or Mattie Pawlowic (email@example.com) and visit our websites (https://modeofactiondundee.org) and (https://pawlowiclab.org). Applications should be submitted via the Dundee jobs portal (www.dundee.ac.uk/hr/uodrecruitment/jobvacancies/).
The University’s statement on the use of animals in research can be found here: https://www.dundee.ac.uk/research/governance-policy/policyroadmap/statement-on-use-of-animals/
The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high-quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.
The University of Dundee is one of the UK’s leading universities – internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Conveniently located on the banks of River Tay, our main city-centre campus is at the heart of Dundee – an up-and-coming, friendly, compact and affordable city with a rich heritage in design and technology. Just a short walk from the V&A Museum of Design Dundee, we’re close to both the train and bus stations. We also have campuses at Ninewells Hospital and in Kirkcaldy which are easily accessible via local transport links.
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